The impact of modern treatment principles may have eliminated lithium-induced renal failure

Journal of Psychopharmacology
Harald AiffJan Svedlund

Abstract

We have previously shown that lithium can cause end-stage renal disease (ESRD): however, this serious side-effect of lithium in prophylactic treatment of mood disorders may reflect the treatment regime of the 1960s and 1970s. Today's modern treatment routines, intended to reduce or eliminate lithium-induced ESRD (Li-ESRD), were introduced in Sweden in the early 1980s. The aim of the present study was to test the hypothesis that these routines have eliminated the risk of Li-ESRD. We used the Swedish Renal Registry to identify patients on renal replacement therapy (RRT), treated with dialysis or renal transplantation, with suspected Li-ESRD in two regions of Sweden with altogether about three million inhabitants. We reviewed their medical records to verify the exposure to lithium treatment, the diagnosis of Li-ESRD and the date of starting the lithium treatment. We found 32 RRT patients in whom lithium treatment was the sole or main contributing cause of ESRD. The starting year of their lithium treatment was between 1965-1980 in all patients. No patient started lithium treatment later than 1980. Modern lithium treatment may have eliminated the risk of Li-ESRD. Our findings support the continued use of lithium as a safe drug for t...Continue Reading

References

Sep 1, 1977·Kidney International·J HestbechS Olsen
Dec 1, 1981·Drugs·H E Hansen
Jan 1, 1959·Psychopharmacologia·M SCHOU
Jan 1, 1959·Bibliotek for laeger·M SCHOU
Jan 27, 2005·Scandinavian Journal of Urology and Nephrology·S SchönJ Ahlmén
Nov 15, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nader BassiliosUNKNOWN Réseau Néphropar
Nov 27, 2009·Kidney International·Hans BendzMattias Aurell
May 11, 2010·Neuropsychobiology·Alessandra M A NivoliEduard Vieta
May 21, 2010·Journal of Affective Disorders·John TredgetGeorge Kirov

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Citations

Aug 19, 2014·Expert Review of Neurotherapeutics·Genevieve Curran, Arun Ravindran
Jun 21, 2015·International Journal of Bipolar Disorders·Manuel E Fuentes SalgadoMark A Frye
Jun 6, 2015·International Journal of Bipolar Disorders·Abed N AzabR H Belmaker
Nov 19, 2015·Journal of the American Society of Nephrology : JASN·Mohammad AlsadyTheun de Groot
Nov 29, 2015·The Lancet. Psychiatry·John M DavisFrank C Brosius
Oct 16, 2015·International Journal of Psychiatry in Medicine·Mashal Khan, Rif S El-Mallakh
Mar 5, 2015·Journal of Psychopharmacology·Harald AiffJan Svedlund
Sep 12, 2015·The Lancet. Psychiatry·Allan H Young
Aug 16, 2017·BJPsych Bulletin·Sumeet Gupta, Udayan Khastgir
Apr 28, 2020·Bipolar Disorders·Karthik KovvuruWisit Cheungpasitporn
Jun 30, 2018·The Mental Health Clinician·Anna K BeasleyErica C Garcia-Pittman
Oct 20, 2017·Acta Psychiatrica Scandinavica·L V KessingR W Licht
Dec 3, 2016·International Journal of Bipolar Disorders·Michael Gitlin
Oct 9, 2018·Acta Psychiatrica Scandinavica·L Vedel KessingR W Licht
Aug 12, 2021·Physiological Genomics·Theun de GrootRon Korstanje

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