The Impact of Muscle and Adipose Tissue on Long-term Survival in Patients With Stage I to III Colorectal Cancer

Diseases of the Colon and Rectum
Jessica J HopkinsMichael B Sawyer

Abstract

Computed tomography-derived body composition parameters are emerging prognostic factors in colorectal cancer. This study aimed to determine the roles of sarcopenia, myosteatosis, and obesity as independent and overlapping parameters in stage I to III colorectal cancer. This is a retrospective cohort study from a prospectively collected database. Multivariate Cox proportional hazards models were performed to assess the associations between body composition parameters and survival. All patients were seen in a tertiary care cancer center. Adult patients with stage I to III colorectal cancer, undergoing curative resection from 2007 to 2009, were included. Computed tomography-derived quantification of skeletal muscle and adipose tissues was used to determine population-specific cutoffs for sarcopenia, myosteatosis, and total adiposity. Primary outcome measures were overall, recurrence-free, and cancer-specific survival. In the 968 patients included, there were a total of 254 disease recurrences and 350 deaths. Body mass index and CT-derived measures of adiposity did not result in worse survival outcomes. Sarcopenia was independently predictive of worse overall (HR, 1.45; 95% CI, 1.16-1.84), recurrence-free (HR, 1.32; 95% CI, 1.00-1....Continue Reading

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Citations

Jul 3, 2019·Leukemia & Lymphoma·Nicole M MueskeEtan Orgel
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