The impact of mycophenolate mofetil dosing patterns on clinical outcome after renal transplantation

Clinical Transplantation
R P PelletierR M Ferguson

Abstract

Mycophenolate mofetil (MMF) has proven to be a very effective drug for the prevention of acute rejection following renal transplantation when dosed as prescribed at 2 or 3 g/d. However, circumstances arise in clinical transplantation where the dose must be lowered, either to avoid drug toxicity or because of concurrent infection. The impact on the incidence of acute rejection and graft survival when the MMF dose must be lowered has not previously been investigated. In this study, a cohort of 721 kidney transplant recipients who received immunosuppression using MMF in conjunction with cyclosporine and prednisone and OKT3 (n = 425) or Simulect (n = 296) induction were evaluated. Clinical outcomes were compared and contrasted between patients with and without MMF dose changes within the first year post-transplantation. The majority of patients (70.3%, n = 507) had at least one dose change within the first post-transplant year. Compared with the 214 patients who did not have a dose change, these patients had a much higher incidence of acute rejection within the first post-transplant year (23.3% vs. 3.7%, p < 0.001). This resulted in a significantly decreased 3-yr death-censored graft survival (76.3% vs. 88.3%, p = 0.003). The incid...Continue Reading

References

Apr 1, 1995·Kidney International·F G CosioR M Ferguson
Dec 1, 1995·Therapeutic Drug Monitoring·L M Shaw, I Nowak
Nov 15, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·D DeNofrioL M Shaw

❮ Previous
Next ❯

Citations

Nov 2, 2004·Transplant International : Official Journal of the European Society for Organ Transplantation·Karen L HardingerMark A Schnitzler
May 18, 2010·European Journal of Clinical Pharmacology·Zhang Wei XiaXie Jun Jie
Sep 15, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Leah KleinmanMary Kay Margolis
Jul 28, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nassim KamarLionel Rostaing
Jul 7, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gabor TelkesArgiris Asderakis
Sep 11, 2012·Transplantation·Sapna ShahMuhammad M Yaqoob
May 14, 2009·Therapeutics and Clinical Risk Management·Pranav DalalLorenzo Gallon
Aug 11, 2007·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Katarina ObrencevićMirjana Mijusković
Aug 11, 2010·World Journal of Gastroenterology : WJG·Giorgos BamiasSpiros D Ladas
Jan 30, 2014·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Eirini SavvidakiDimitrios S Goumenos
Jul 1, 2005·Expert Review of Clinical Immunology·Hans W Sollinger
Aug 11, 2007·Expert Opinion on Drug Safety·Guido Filler, Ilan Buffo
Apr 19, 2005·Expert Opinion on Investigational Drugs·Anamaria Jorga, Atholl Johnston
Sep 13, 2005·Renal Failure·M BalalU Erken
Aug 28, 2010·Expert Opinion on Drug Safety·Klemens BuddePetra Glander
May 28, 2004·Expert Opinion on Pharmacotherapy·Klemens BuddeHans-Hellmut Neumayer
Jun 20, 2013·Current Medical Research and Opinion·Chaitanya PantThomas J Sferra
Nov 12, 2013·Transplantation Reviews·Roman Reindl-Schwaighofer, Rainer Oberbauer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society of Nephrology : JASN
Greg A KnollCarl Van Walraven
Transplant International : Official Journal of the European Society for Organ Transplantation
Karen L HardingerM A Schnitzler
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Maurizio SalvadoriERL B301 Study Groups
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
K BuddeERL B302 Study Group
© 2022 Meta ULC. All rights reserved