The impact of native leptomeningeal collateralization on rapid blood flow recruitment following ischemic stroke.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Atsushi KanokeJialing Liu

Abstract

The leptomeningeal collateral status is an independent predictor of stroke outcome. By means of optical coherent tomography angiography to compare two mouse strains with different extent of native leptomeningeal collateralization, we determined the spatiotemporal dynamics of collateral flow and downstream hemodynamics following ischemic stroke. A robust recruitment of leptomeningeal collateral flow was detected immediately after middle cerebral artery (MCA) occlusion in C57BL/6 mice, with continued expansion over the course of seven days. In contrast, little collateral recruitment was seen in Balb/C mice during- and one day after MCAO, which coincided with a greater infarct size and worse functional outcome compared to C57BL/6, despite a slight improvement of cortical perfusion seven days after MCAO. Both strains of mice experienced a reduction of blood flow in the penetrating arterioles (PA) by more than 90% 30-min after dMCAO, although the decrease of PA flow was greater and the recovery was less in the Balb/C mice. Further, Balb/C mice also displayed a prolonged greater heterogeneity of capillary transit time after dMCAO in the MCA territory compared to C57BL/6 mice. Our data suggest that the extent of native leptomeningeal ...Continue Reading

References

Nov 4, 2000·Stroke; a Journal of Cerebral Circulation·A MajidC Y Hsu
Jul 9, 2002·Journal of Neuroscience Methods·Li ZhangMichael Chopp
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Mariana BroziciBerend Hillen
Jan 7, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Armin HelischWolfgang Schaper
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Nozomi NishimuraDavid Kleinfeld
Apr 12, 2007·Physiological Genomics·Dan ChalothornJames E Faber
Jan 29, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Andy Y ShihDavid Kleinfeld
Feb 4, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hua ZhangJames E Faber
Jun 3, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Glenn A ArmitageIan R Winship
Dec 16, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David S LiebeskindUNKNOWN Warfarin–Aspirin Symptomatic Intracranial Disease (WASID) Investigators
Jan 6, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carol KilkennyUNKNOWN National Centre for the Replacement, Refinement and Reduction of Amimals in Research
May 20, 2011·Translational Stroke Research·R Anthony DefazioVictoria Ohanna
May 28, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·James E FaberStephen E Epstein
Sep 13, 2011·Microvascular Research·Suzane M MarquesSilvia P Andrade
Nov 3, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sune N Jespersen, Leif Østergaard
Sep 18, 2012·PloS One·Princess I Imoukhuede, Aleksander S Popel
Feb 28, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Leif ØstergaardGrethe Andersen
Nov 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chongran SunJialing Liu
Dec 3, 2013·Progress in Neurobiology·Jialing LiuGuo-Yuan Yang
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators
Mar 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yosuke AkamatsuJialing Liu
Feb 24, 2016·Stroke; a Journal of Cerebral Circulation·Olvert A BerkhemerUNKNOWN MR CLEAN Investigators
Nov 12, 2016·Stroke; a Journal of Cerebral Circulation·Yasuo NishijimaJialing Liu
Dec 26, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Itxaso Azkune CalleJuan Carlos Garcia-Monco
Feb 12, 2017·Stroke; a Journal of Cerebral Circulation·Yu-Chieh Jill KaoYen-Yu Ian Shih
Jun 16, 2017·Journal of Biomedical Optics·Ruikang K WangShaozhen Song
Jul 8, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wojciech RzechorzekJames E Faber
Oct 14, 2017·AJNR. American Journal of Neuroradiology·A P JadhavUNKNOWN SWIFT PRIME investigators
Oct 21, 2018·World Neurosurgery·Guilherme Santos PiedadeChristoph J Griessenauer
Nov 6, 2018·Journal of Neurointerventional Surgery·Ali AlawiehAlejandro M Spiotta
Jul 25, 2019·Stroke; a Journal of Cerebral Circulation·Philippe BonninNathalie Kubis

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

GraphPad
Prism
DOCT

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved