The impact of neonatal exposure to 17alpha-ethynylestradiol on the development of kisspeptin neurons in female rats

Reproductive Toxicology
Miwa TakahashiMidori Yoshida

Abstract

Neonatal exposure to 17alpha-ethynylestradiol (EE) at relatively low doses leads to delayed effects characterized by the early onset of age-related anovulation. Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV), located at the anterior hypothalamus, are proposed to play key roles in appearance of these delayed effects after maturation. To understand the initial changes, we investigated Kiss1 mRNA expression in the anterior and posterior hypothalamus before weaning in female rats that received neonatal exposure to EE at various doses (0.002-2000μg/kg). The level of Kiss1 mRNA in the anterior hypothalamus was decreased from 0.002μg/kg which did not induce delayed effects. In the posterior hypothalamus, Kiss1 mRNA expression did not differ among the groups except 2000μg/kg group. These results suggest that neonatal exposure to EE affects the development of kisspeptin neurons and kisspeptin neurons in the AVPV are highly susceptible to neonatal EE treatment.

References

Oct 1, 1976·Acta Endocrinologica·K D Döhler, W Wuttke
Sep 1, 1983·Journal of Reproduction and Fertility·K TayaS Sasamoto
Mar 17, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S H Swan
Jan 6, 2007·Endocrinology·Alexander S KauffmanManuel Tena-Sempere
Jul 29, 2010·Journal of Molecular Neuroscience : MN·Ken TakumiHitoshi Ozawa
Dec 31, 2010·Endocrinology·Sarah M DickersonAndrea C Gore
Apr 13, 2011·The Journal of Comparative Neurology·Jinyan Cao, Heather B Patisaul
Jun 17, 2011·Biology of Reproduction·Juan RoaManuel Tena-Sempere

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Citations

Oct 16, 2016·Journal of Analytical Methods in Chemistry·Chalder Nogueira NunesSueli Pércio Quináia

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