The impact of network biology in pharmacology and toxicology

SAR and QSAR in Environmental Research
G Panagiotou, Olivier Taboureau

Abstract

With the need to investigate alternative approaches and emerging technologies in order to increase drug efficacy and reduce adverse drug effects, network biology offers a novel way of approaching drug discovery by considering the effect of a molecule and protein's function in a global physiological environment. By studying drug action across multiple scales of complexity, from molecular to cellular and tissue level, network-based computational methods have the potential to improve our understanding of the impact of chemicals in human health. In this review we present the available large-scale databases and tools that allow integration and analysis of such information for understanding the properties of small molecules in the context of cellular networks. With the recent advances in the omics area, global integrative approaches are necessary to cope with the massive amounts of data, and biomedical researchers are urged to implement new types of analyses that can lead to new therapeutic interventions with increased safety and efficacy compared with existing medications.

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Citations

Oct 22, 2013·Trends in Pharmacological Sciences·Xuan LiuDe-An Guo
Mar 29, 2013·SAR and QSAR in Environmental Research·A T García-Sosa, U Maran
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Jul 12, 2017·Molecular Informatics·Baptiste BoezioOlivier Taboureau

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Software Mentioned

DailyMed
PK
CMAP
Connectivity Map ( CMAP )
PubChem BioAssay
ChemProt
STITCH
ACToR
TOXNET
Microarray Rank Query ( MARQ )

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