The Impact of Number of Cycles of Neoadjuvant Chemotherapy on Survival of Patients Undergoing Interval Debulking Surgery for Stage IIIC-IV Unresectable Ovarian Cancer: Results From a Multi-Institutional Study

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Giorgio BoganiDomenica Lorusso

Abstract

Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) may be a valuable treatment option in advanced ovarian cancer when primary cytoreduction is not feasible. However, a consensus on the ideal number of NACT cycles is still lacking. In the present investigation, we aimed to evaluate how number of cycles of NACT influenced patients' outcomes. Data of consecutive patients undergoing NACT and IDS were retrospectively reviewed in 4 Italian centers, and survival outcomes were evaluated. Overall, 193 patients were included. Cycles of NACT were 3, 4, and at least 5 in 77 (40%), 74 (38%), and 43 (22%) patients, respectively. Patients undergoing 3 cycles experienced a similar disease-free survival (hazard ratio [HR], 1.12; 95% confidence interval [CI], 0.89-1.65; P = 0.20) but an improved overall survival (HR, 1.64; 95% CI, 1.05-2.4; P = 0.02) in comparison to patients receiving at least 4 cycles. Five-year overall survival was 46% and 31% for patients having 3 and at least 4 cycles. Ten-year overall survival was 26% and 18% for patients having 3 and at least 4 cycles (HR, 1.70; 95% CI, 1.13-2.55; P = 0.009). Using multivariate analysis, we observed that only Eastern Cooperative Oncology Group performance status ...Continue Reading

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Citations

Oct 28, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ying L LiuKara Long Roche
Feb 6, 2021·The Cochrane Database of Systematic Reviews·Sarah L ColeridgeJo Morrison
Oct 31, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Shih-Ern YaoJim Nicklin
Oct 31, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Francesco RaspagliesiDomenica Lorusso
Mar 10, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Ciro PinelliHooman Soleymani Majd
Nov 7, 2019·The Cochrane Database of Systematic Reviews·Sarah L ColeridgeJo Morrison
Jul 6, 2018·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·P Horvath, A Königsrainer
Jun 12, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ying L LiuWilliam Tew
Nov 28, 2018·Journal of Gynecologic Oncology·Giorgio BoganiFrancesco Raspagliesi
Aug 14, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andreas du BoisIgnace Vergote
Aug 27, 2021·Future Oncology·Amaranta D CraigJocelyn S Chapman

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