PMID: 16538036Mar 16, 2006Paper

The impact of nutrition of the cumulus oocyte complex and embryo on subsequent development in ruminants

The Journal of Reproduction and Development
Jeremy G Thompson

Abstract

Cumulus-oocyte complexes (COCs) and early embryos rely on a histotrophic nutrition source for energy production and the synthesis of macromolecules. There is accumulating evidence suggesting that the balance of supply and demand for energy and other anabolic substrates during oocyte maturation and very early stages of development programmes subsequent developmental potential, and this may include subsequent fetal growth trajectory. One example is the role of glucose (Glc) during cumulus-oocyte complex maturation. Glucose is an essential nutrient for maturation, especially its role during cumulus expansion. Our laboratory has shown that during in vitro culture, too little glucose during cumulus-oocyte complex maturation affects meiotic competence. We have focussed on glucose (Glc) metabolism through the hexosamine biosynthesis pathway (HBP) during COC maturation in vitro. The HBP in somatic cells is regarded as a "fuel-sensing" pathway and its interaction with cell signalling systems and transcriptional regulation is increasingly apparent. Up-regulation of the HBP during oocyte maturation in vitro has negative consequences for subsequent development. Another example is the role of hypoxia (low O2) during peri-compaction developm...Continue Reading

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Citations

Dec 23, 2011·ISRN Obstetrics and Gynecology·Jacira Ribeiro Campos, Ana Carolina Japur de Sá Rosa-E-Silva
May 11, 2007·Theriogenology·R Singh, K D Sinclair
Nov 10, 2006·Theriogenology·Robert B Gilchrist, Jeremy G Thompson
Sep 17, 2009·Reproduction in Domestic Animals = Zuchthygiene·A E F SilvaJ L Rodrigues
Nov 30, 2012·Reproduction in Domestic Animals = Zuchthygiene·G M AlvarezP D Cetica
Oct 5, 2014·Cellular and Molecular Life Sciences : CMLS·Ling GuQiang Wang
Jan 30, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D K de SouzaA A M Rosa e Silva
Nov 29, 2008·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B LingZ G Tian
Mar 8, 2012·Reproduction, Fertility, and Development·Tom P FlemingJudith J Eckert
Jul 19, 2013·Reproduction, Fertility, and Development·Cynthia GutniskyPablo D Cetica
Jan 8, 2008·Human Reproduction Update·Robert B GilchristJeremy G Thompson
Jul 1, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Seda KarabulutIlknur Keskin
Nov 8, 2020·Domestic Animal Endocrinology·C A Rosales-NietoA Veiga-Lopez
Mar 7, 2021·Reproductive Sciences·Shogo ImanakaHiroshi Kobayashi

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