The impact of obesity on oesophageal acid exposure time on and off proton pump inhibitor therapy

Alimentary Pharmacology & Therapeutics
S L ShahMichael D Crowell

Abstract

Obesity is associated with increased oesophageal acid exposure time (AET) in patients with gastro-oesophageal reflux (GER), and may decrease the effects of proton pump inhibitors (PPIs). To evaluate the effects of increased body mass on the ability of PPI therapy to decrease AET in patients with reflux symptoms. Acid exposure time profiles collected from adult patients using wireless pH-metry while on or off PPI therapy was retrospectively reviewed. Patients were separated into five body mass index (BMI) categories as defined by the World Health Organization. A multivariable logistic regression evaluated the association between abnormal AET and BMI groups while controlling for age, gender and pH capsule placement methods. The study group comprised 968 patients with 336 (34.7%) studied on a PPI and 632 (65.3%) studied off PPI therapy. AET (total greater than 5.3%) was found more frequently in the overweight (67%) and obese classes (74-80%) compared to those who were normal weight (40%) while off acid-suppressing medications (P < 0.001). No significant differences were found between these groups when studied on acid-suppressing medications, and the proportion of patients with abnormal AET across BMI classes was similar regardless...Continue Reading

References

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Citations

Jul 23, 2016·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Byungkyu AhnNayoung Kim
May 3, 2018·Obesity Surgery·Simon ErridgeSanjay Purkayastha
Aug 24, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Benjamin D RogersC Prakash Gyawali
Feb 25, 2021·Critical Care : the Official Journal of the Critical Care Forum·Brian L Erstad, Jeffrey F Barletta

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