The impact of obesity on outcomes in patients receiving extracorporeal life support.

Artificial Organs
Nathaniel Christian-MillerPeyman Benharash

Abstract

Extracorporeal life support (ECLS) has been increasingly utilized to manage cardiac and pulmonary dysfunction. The impact of obesity on outcomes of ECLS is poorly defined. The purpose of the study was to compare in-hospital mortality, resource use, complications, and readmissions in obese versus non-obese patients receiving ECLS. We performed a retrospective cohort study of all adult ECLS patients with and without an obesity diagnosis using the 2010-2016 Nationwide Readmissions Database (NRD). Mortality, length of stay (LOS), hospital charges, complications, and readmissions were evaluated using multivariable logistic and linear regression. Of 23 876, patients who received ECLS, 1924 (8.1%) were obese. Obese patients received ECLS more frequently for respiratory failure (29.5% vs. 23.7%, P = .001). After adjustment for patient and hospital factors, obesity was not associated with increased odds of mortality (AOR = 1.06, P = .44) and was associated with decreased LOS (13.7 vs. 21.2 days, P < .001), hospital charges ($171 866 vs. $211 445, P < .001), and 30-day readmission (AOR = 0.71, P = .03). Obesity was also associated with reduced odds of hemorrhage (AOR = 0.43, P < .001), neurologic complications (AOR = 0.55, P = .004), and...Continue Reading

References

Nov 24, 1999·Artificial Organs·B P FuhrmanE R Rosenkranz
Jun 1, 2010·Journal of the American College of Surgeons·Martin A MakaryLinda P Fried
Aug 2, 2013·Diabetes Care·Vojtech Hainer, Irena Aldhoon-Hainerová
Aug 21, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Peter AdamsIlan Rubinfeld
Jan 21, 2014·Progress in Cardiovascular Diseases·Jongha ParkKamyar Kalantar-Zadeh
Feb 18, 2014·Journal of the American College of Cardiology·Carl J LavieSteven N Blair
Mar 5, 2014·Acta Anaesthesiologica Scandinavica·J SwolT A Schildhauer
Oct 12, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Christopher M SauerPramod Bonde
Nov 29, 2014·Thoracic Surgery Clinics·Mauer BiscottiMatthew Bacchetta
Aug 25, 2015·The Annals of Thoracic Surgery·Zachary N KonBartley P Griffith
Jun 17, 2016·Critical Care : the Official Journal of the Critical Care Forum·Dominique J PepperPeter Q Eichacker
Feb 23, 2017·Critical Care : the Official Journal of the Critical Care Forum·Yue-Nan NiZong-An Liang
Mar 1, 2017·The Annals of Thoracic Surgery·Mauer BiscottiMatthew Bacchetta
Mar 8, 2017·Critical Care : the Official Journal of the Critical Care Forum·Myles SmithHergen Buscher
Mar 10, 2017·Annals of Translational Medicine·Evgeny PavlushkovKamen Valchanov
Jul 6, 2017·Intensive Care Medicine·John MuscedereKenneth Rockwood
Aug 15, 2017·The Annals of Thoracic Surgery·Brandon R RosvallAnsar Hassan
Sep 1, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Shameen SalamAbhijit Duggal
Oct 19, 2017·The Journal of Thoracic and Cardiovascular Surgery·Emily M ToddRoss M Bremner
Nov 7, 2017·Interactive Cardiovascular and Thoracic Surgery·Daisuke YoshiokaKoji Takeda
Dec 10, 2017·Journal of Thoracic Disease·Gabriel LoorAmit Parulekar
Dec 15, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Nikola DobrilovicJaishankar Raman
Sep 27, 2018·Journal of Critical Care·Bishoy Zakhary, Beno W Oppenheimer
Mar 20, 2019·Journal of the American College of Surgeons·Mary M MrduttClaire L Isbell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.