The impact of obesity on the course and outcome of acute pancreatitis.

Obesity Surgery
Mohammed Abu Hilal, Thomas Armstrong

Abstract

Obesity has reached epidemic proportions in many countries and is an established risk factor in many chronic illnesses, but its role in acute illness is less clear. Pancreatologists have long recognized obesity as a risk factor for a poor outcome in severe acute pancreatitis. There are now several studies that have identified obesity as a primary risk factor for developing local complications (abscess, pseudocyst, necrosis), organ failure, and death. Indeed, meta-analysis of these studies gives a relative risk of 4.3 for local complications, 2.0 for systemic complications, and 2.1 for death. This has led to proposed modifications of acute pancreatitis scoring systems to include obesity as an independent primary predictive factor of severe disease. Obesity is associated with a low-grade inflammatory state, which may predispose obese patients to such complications. Furthermore, visceral obesity and visceral adipose tissue may be particularly important in underlying the pathophysiology of these observations.

References

Nov 1, 1992·Gastroenterology·I KarimganiP A Banks
Nov 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·K A Porter, P A Banks
Jan 1, 1993·Annales de chirurgie·E L Bradley
Apr 1, 1993·The British Journal of Surgery·I C FunnellI N Marks
Feb 1, 1996·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·G TalaminiG Cavallini
Aug 26, 1998·The American Journal of Gastroenterology·J Suazo-BaráhonaM Peláez-Luna
Oct 28, 1998·Digestive Diseases and Sciences·C J Tsai
Oct 20, 2000·Pancreas·K I HalonenR K Haapiainen
Jul 10, 2001·The British Journal of Surgery·B GloorM W Büchler
Nov 19, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Carlos M MeryGuillermo Robles-Díaz
Feb 28, 2004·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·C D JohnsonM J Campbell
Feb 28, 2004·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·J MartínezM Pérez-Mateo
Oct 28, 2004·The Journal of Clinical Endocrinology and Metabolism·Luis Alberto VázquezJosé Antonio Amado
Jan 25, 2005·Current Diabetes Reports·Yong-Ho Lee, Richard E Pratley
Mar 22, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·J MartínezM Pérez-Mateo
Apr 26, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Georgios I PapachristouDavid C Whitcomb

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Citations

Mar 3, 2012·Forensic Science, Medicine, and Pathology·Roger W Byard
Nov 13, 2009·World Journal of Gastroenterology : WJG·Jean-Louis FrossardCatherine M Pastor
Oct 4, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Chathur AcharyaVijay P Singh
Dec 3, 2014·European Journal of Internal Medicine·Agostino Di Ciaula, Piero Portincasa
Apr 12, 2012·World Journal of Surgery·D P O'LearyH P Redmond
Feb 16, 2016·The American Journal of Pathology·Krutika PatelVijay P Singh
Sep 11, 2013·The Kaohsiung Journal of Medical Sciences·Wei-Sin LeeWan-Long Chuang
Aug 20, 2010·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Piotr DanielEwa Małecka-Panas
Sep 10, 2014·Best Practice & Research. Clinical Gastroenterology·Leonilde BonfratePiero Portincasa
Dec 2, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jongwon ParkSok Won Han
Dec 4, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Rakesh PremkumarJohn A Windsor
Sep 10, 2014·Nutrition·Byung Ok KwakSochung Chung
Nov 6, 2015·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Alexandre de Figueiredo FerreiraIure Kalinine Ferraz de Souza
Jun 14, 2017·Pancreas·Ashwinee NatuPeter J W Lee
Jan 5, 2013·The American Journal of Gastroenterology·Maxim S Petrov
Jun 25, 2019·European Journal of Gastroenterology & Hepatology·Jiarong XieLei Xu
Jul 19, 2017·Current Opinion in Gastroenterology·Biswajit KhatuaVijay P Singh
Apr 10, 2019·Lipids in Health and Disease·Yanbing DingGuotao Lu
May 20, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ramin NiknamFardad Ejtehadi
Apr 8, 2019·The American Journal of Pathology·Biswajit KhatuaVijay P Singh

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