The impact of obstructive sleep apnea on nonalcoholic fatty liver disease in patients with severe obesity

Obesity
Peter BenottiChristopher Still

Abstract

Obstructive sleep apnea (OSA) is common among candidates for bariatric surgery. OSA and its associated intermittent hypoxia have been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis. A large cohort of bariatric surgery patients was studied in an effort to explore the relationship between OSA severity, hypoxia, metabolic syndrome, and the severity of NAFLD. Bariatric surgery candidates who underwent both polysomnography and liver biopsy were studied. The severity of OSA as determined by the apnea-hypopnea index (AHI) and parameters of hypoxia was studied in relation to extent of abnormalities of liver histology as measured by the presence of hepatic steatosis, inflammation, and fibrosis. The study cohort included 362 patients with a mean age of 46.2 years and BMI of 49.9 kg/m(2) . On the basis of AHI, 26% of the cohort had no OSA, 32% mild OSA, 22% moderate OSA, and 20% severe OSA. For the study subjects without metabolic syndrome, positive correlations were found between OSA severity, as measured by AHI, and parameters of hypoxia, with the severity of NAFLD. OSA severity and its accompanying hypoxia are associated with the severity of NAFLD.

References

Apr 29, 1993·The New England Journal of Medicine·T YoungS Badr
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Jungermann, T Kietzmann
Mar 5, 2002·American Journal of Respiratory and Critical Care Medicine·Mary S M IpKaren S L Lam
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Florence TannéLawrence Serfaty
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Oct 11, 2005·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Koichiro Tatsumi, Toshiji Saibara
May 10, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·K G M M AlbertiJ Shaw
Oct 26, 2006·Journal of Clinical Gastroenterology·Kaushal MadanAnoop Saraya
Apr 20, 2007·Sleep Medicine Reviews·Kristen L KnutsonEve Van Cauter
Jan 1, 2008·The Journal of Surgical Research·Thomas A BroughanT Kent Teague
Jul 24, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Poonam MishraZobair M Younossi
Nov 8, 2008·American Journal of Respiratory and Critical Care Medicine·Vsevolod Y PolotskyAlan R Schwartz
Aug 25, 2009·Clinics in Chest Medicine·Neomi Shah, Francoise Roux
Oct 17, 2009·Clinical Science·Anne-Christine PiguetJean-François Dufour
Jul 16, 2010·Mediators of Inflammation·Paschalis SteiropoulosDemosthenes Bouros
Mar 29, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiManirath Srishord
Jun 28, 2011·Journal of Hepatology·Judith Aron-WisnewskyJean-Louis Pépin
Jul 9, 2011·Journal of Applied Physiology·Christian ReinkeVsevolod Y Polotsky
Sep 20, 2011·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Jason J RasmussenMohamed R Ali
May 30, 2012·BMC Medical Informatics and Decision Making·G Craig WoodGlenn S Gerhard
Apr 17, 2013·American Journal of Epidemiology·Paul E PeppardKhin Mae Hla
Apr 5, 2015·Digestive Diseases and Sciences·Kathleen E CoreyRaymond T Chung
Jun 10, 2015·JAMA : the Journal of the American Medical Association·Mary E Rinella

❮ Previous
Next ❯

Citations

Jul 14, 2016·Multidisciplinary Respiratory Medicine·Thiago Thomaz MafortAgnaldo José Lopes
Jun 1, 2017·The Nurse Practitioner·Jessica Wisocky, Sonali Paul
Jun 12, 2020·World Journal of Gastroenterology : WJG·Ilaria UmbroMaria Del Ben
Nov 17, 2020·Frontiers in Medicine·Stephania C IsazaCarmelo García-Monzón
Nov 3, 2020·World Journal of Gastroenterology : WJG·Alejandro Campos-MurguíaRicardo U Macías-Rodríguez
Feb 13, 2021·Journal of Clinical Medicine·Kristoffer KjærgaardKaren Louise Thomsen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.