The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations

Mediators of Inflammation
Firat UygurMeltem Tor

Abstract

The aim of the present study was to evaluate the impact of obstructive sleep apnoea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on circulating ischaemia-modified albumin (IMA) concentrations. The study included 97 newly diagnosed OSAS patients and 30 nonapnoeic controls. Blood samples were obtained in the morning after polysomnography. After 3 months of CPAP treatment, 31 patients with moderate-severe OSAS were reassessed for serum IMA concentrations. Significantly higher serum IMA concentrations were measured in the OSAS group than in the control group [0.518 ± 0.091 absorbance units (ABSU), 0.415 ± 0.068 ABSU, P < 0.001]. Serum IMA concentrations correlated significantly with the apnoea-hypopnoea index, mean SaO2, desaturation index, and C-reactive protein concentrations. Multiple logistic regression analyses showed that OSAS increased the serum IMA concentration independent of age, sex, body mass index, smoking habit, and cardiovascular disease. After 3 months of treatment with CPAP, OSAS patients had significantly lower serum IMA concentrations (0.555 ± 0.062 ABSU to 0.431 ± 0.063 ABSU, P < 0.001). The results showed that OSAS is associated with elevated concentrations of IMA, which c...Continue Reading

References

Apr 29, 1993·The New England Journal of Medicine·T YoungS Badr
Apr 19, 2000·JAMA : the Journal of the American Medical Association·F J NietoT G Pickering
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Larissa DyugovskayaLena Lavie
Jul 18, 2002·American Journal of Respiratory and Critical Care Medicine·Yüksel PekerJan Carlson
Feb 15, 2003·Sleep Medicine Reviews·Lena Lavie
Dec 13, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Majed A RefaaiCharles S Eby
Feb 16, 2006·Chest·Murat CanSelda Demirtas
Dec 5, 2006·Cerebrovascular Diseases·Halim AbboudPierre Amarenco
Sep 18, 2007·The American Journal of Emergency Medicine·Suleyman TurediMurat Topbas
Jan 18, 2008·Journal of Clinical Laboratory Analysis·Luiz Carlos CichotaJosé Edson Paz da Silva
Jun 2, 2009·The European Respiratory Journal·L Lavie, P Lavie
Jul 25, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Konstantinos KazanisAmalia Dionyssiou-Asteriou
Sep 12, 2009·Drug Metabolism and Pharmacokinetics·David C Gaze
Sep 2, 2011·Sleep & Breathing = Schlaf & Atmung·Charalampos MermigkisSophia E Schiza
May 23, 2012·Clinical and Experimental Dermatology·M OzdemirC Peru
Jun 12, 2013·European Neurology·Murat CanGulbun Asuman Yuksel
Feb 26, 2014·BMC Neuroscience·Şerefden AçıkgözBektaş Açıkgöz
Sep 17, 2014·European Journal of Clinical Investigation·Serkan OzbenTomris Ozben
Oct 30, 2014·Biochemia Medica·Ozgur AydinNecat Yılmaz

❮ Previous
Next ❯

Citations

Mar 27, 2020·Sleep & Breathing = Schlaf & Atmung·Mustafa DügerGözde Ülfer
Aug 31, 2016·European Journal of Clinical Investigation·Rosa María AgraJohn P H Wilding
Mar 7, 2021·Children·Emanuela di PalmoAndrea Pession

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.