The impact of opioid-induced constipation among chronic pain patients with sufficient laxative use

International Journal of Clinical Practice
Robert J LoCasaleKarin S Coyne

Abstract

The impact of sufficient laxative use on opioid-induced constipation (OIC) is not known. To understand the experience and symptom burden over time among chronic non-cancer pain patients with OIC who are sufficient laxative users. A prospective longitudinal study was conducted in United States, Canada, Germany and UK which included medical record abstraction, patient surveys and physician surveys. Patients on daily opioid therapy for ≥ 4 weeks for chronic non-cancer pain with OIC were recruited from physician offices and completed the survey at Baseline and Weeks 2, 4, 6, 8, 12, 16, 20 and 24. Sufficient laxative use was defined as at least one laxative remedy 4 or more times in the prior 2 weeks. Of the 489 patients who completed the Baseline survey and met OIC criteria, 234 (48%) were categorised as sufficient laxative users; 65% were female; 90% were white and 75 (32%) maintained sufficient laxative use for > 7 of the 8 follow-up periods. Patient Assessment of Constipation-Symptom (PAC-SYM) and Patient Assessment of Constipation-Quality of Life (PAC-QOL) scores indicated moderate symptom severity and impact. PAC-SYM and PAC-QOL scores remained relatively unchanged over time with a maximum score change of 0.5 points. Work prod...Continue Reading

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Citations

Jul 5, 2016·Frontiers in Oncology·Karin S CoyneSam H Ahmedzai
Sep 26, 2017·Pain Practice : the Official Journal of World Institute of Pain·Bart J MorlionTony O'Brien
Jan 1, 2019·Journal of Gastroenterology and Hepatology·Kenichi NishieMasayuki Hanaoka
Oct 9, 2019·The American Journal of Gastroenterology·Borko NojkovWilliam D Chey
Jul 30, 2020·Regional Anesthesia and Pain Medicine·Eugene R Viscusi, Andrew R Viscusi
Aug 21, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·April Hazard VallerandCatherine Datto
Nov 14, 2019·BMC Gastroenterology·Michelle S KellerBrennan M R Spiegel
Feb 3, 2021·Nutrients·Hideki MoriHidekazu Suzuki

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