The impact of oxidative stress on chaperone-mediated human sperm-egg interaction

Human Reproduction
Elizabeth G BromfieldBrett Nixon

Abstract

How does oxidative stress impact upon human sperm-egg interaction and in particular the formation of zona pellucida-receptor complexes on the sperm surface? Oxidative stress during human sperm capacitation resulted in the chemical alkylation of the molecular chaperone heat shock protein A2 (HSPA2), a concomitant reduction in surface expression of the zona pellucida-receptor arylsulphatase A (ARSA) and a severe loss of zona pellucida binding ability. An inability to bind to the zona pellucida is commonly encountered in the defective spermatozoa generated by male infertility patients; however, the underlying mechanisms remain unresolved. Recent studies have revealed that zona pellucida binding is mediated by molecular chaperones, particularly HSPA2, that facilitate the formation of multimeric zona pellucida-receptor complexes on the surface of mammalian spermatozoa during capacitation. Spermatozoa were collected from healthy normozoospermic donors (n = 15). Low levels of oxidative stress were induced in populations of non-capacitated spermatozoa by a 1 h treatment with 4-hydroxynonenal (4HNE) or hydrogen peroxide (H2O2) and then these insults were removed and cells were capacitated for 3 h. Motility, membrane fluidity, protein ty...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K Uchida, E R Stadtman
Apr 1, 1995·Molecular Reproduction and Development·W L Vredenburgh-Wilberg, J J Parrish
Feb 1, 1993·Free Radical Biology & Medicine·E de Lamirande, C Gagnon
Mar 1, 1995·Free Radical Biology & Medicine·E de Lamirande, C Gagnon
Jul 24, 2001·Biology of Reproduction·R RathiB M Gadella
Jun 21, 2002·Developmental Biology·Euridice CarmonaNongnuj Tanphaichitr
Jun 25, 2002·Biology of Reproduction·Julierut TantibhedhyangkulNongnuj Tanphaichitr
Aug 10, 2002·Journal of Assisted Reproduction and Genetics·H S BastiaanD R Franken
Feb 7, 2003·Current Pharmaceutical Design·María Belén HerreroClaude Gagnon
Mar 8, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Françoise Urner, Denny Sakkas
Mar 19, 2003·International Journal of Andrology·C O'FlahertyM T Beconi
Apr 12, 2003·Progress in Lipid Research·Koji Uchida
Oct 17, 2003·Molecular Human Reproduction·R J AitkenM A Baker
May 11, 2004·Mass Spectrometry Reviews·Marina CariniRoberto Maffei Facino
May 15, 2004·Human Reproduction·L LefièvreC L R Barratt
Jul 15, 2004·Journal of Cell Science·Kelly L AsquithR John Aitken
Oct 1, 2004·Molecular Reproduction and Development·Steve TardifJanice L Bailey
Nov 6, 2004·Free Radical Biology & Medicine·Gabriella LeonarduzziGiuseppe Poli
Nov 16, 2004·Chemical Research in Toxicology·David L CarboneDennis R Petersen
Jun 14, 2005·The Journal of Pharmacology and Experimental Therapeutics·David L CarboneDennis R Petersen
Mar 17, 2006·Free Radical Biology & Medicine·Cristián O'FlahertyClaude Gagnon
May 19, 2007·Reproductive Biomedicine Online·Gabor HuszarSinan Ozkavukcu
Jul 24, 2008·The International Journal of Developmental Biology·Harvey M FlormanKeith A Sutton
Aug 30, 2008·Journal of Cellular Physiology·Brett NixonR John Aitken
Dec 17, 2008·Free Radical Biology & Medicine·Eve de Lamirande, Geneviève Lamothe
Jul 17, 2009·Biology of Reproduction·Masanori KimuraTadashi Baba
Sep 15, 2010·Handbook of Experimental Pharmacology·Matthew D DunBrett Nixon
Nov 3, 2010·Asian Journal of Andrology·Andrew T ReidBrett Nixon
Apr 15, 2011·Biology of Reproduction·R John Aitken
Jul 28, 2011·Journal of Cellular Physiology·Brett NixonR John Aitken

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Citations

Feb 9, 2016·Expert Review of Proteomics·Ashok AgarwalLuna Samanta
Apr 23, 2016·Biology of Reproduction·Zamira GibbRobert J Aitken
Apr 8, 2017·Nutrients·Xiao MengHua-Bin Li
Oct 12, 2018·The Journal of Biological Chemistry·Bettina P MihalasBrett Nixon
Jun 18, 2019·Systems Biology in Reproductive Medicine·Elena MorettiCinzia Signorini
Dec 14, 2019·Antioxidants & Redox Signaling·Shenae Louise CafeElizabeth Grace Bromfield
Feb 9, 2020·Antioxidants·Karolina Nowicka-Bauer, Brett Nixon
Jan 26, 2020·Journal of Clinical Medicine·Jessica L H WaltersElizabeth G Bromfield
Apr 24, 2020·Andrologia·Cayde Ritchie, Edmund Y Ko
Oct 1, 2016·Oncotarget·Shi-Kai Jin, Wan-Xi Yang
Aug 7, 2019·The World Journal of Men's Health·Gayatri MohantyLuna Samanta
Jan 2, 2020·Antioxidants & Redox Signaling·Alexandra E PetersJessie M Sutherland
Nov 23, 2016·The Journal of Endocrinology·Shuai Li, Wipawee Winuthayanon
May 14, 2019·The World Journal of Men's Health·Avi HarlevAshok Agarwal
Nov 23, 2019·Antioxidants·Fernando J PeñaCristina Ortega Ferrusola
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Brett NixonElizabeth G Bromfield
Jan 10, 2018·Oxidative Medicine and Cellular Longevity·Bettina P MihalasBrett Nixon
Oct 22, 2020·Seminars in Reproductive Medicine·Robert John Aitken
Apr 30, 2020·MethodsX·Maksim IonovMaria Bryszewska
Jan 30, 2021·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Vanessa Silvestre Innocenti GiorgiPaula Andrea Navarro
Nov 4, 2020·Molecular Reproduction and Development·Peng-Fei ZhangMing Zhang
Nov 28, 2020·Journal of Reproductive Immunology·Natalia Huerta-RetamalMaría José Gómez-Torres
May 4, 2021·Frontiers in Cell and Developmental Biology·Shenae L CafeElizabeth G Bromfield
Aug 28, 2021·International Journal of Molecular Sciences·Shuwen ShanBertram Brenig
Oct 30, 2021·Antioxidants & Redox Signaling·Steven Serafini, Cristian O'Flaherty

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