The impact of panitumumab treatment on survival and quality of life in patients with RAS wild-type metastatic colorectal cancer

Cancer Management and Research
Francesca BattaglinHeinz-Josef Lenz

Abstract

Panitumumab is a fully human monoclonal antibody targeting the epidermal growth factor receptor (EGFR). It is currently approved for the treatment of RAS wild-type (WT) metastatic colorectal cancer (mCRC) in combination with chemotherapy in first- and second-line and as monotherapy in chemorefractory patients. This review will provide an overview of main efficacy data on panitumumab from its early development up to latest evidences, including novel perspectives on predictive biomarkers of anti-EGFRs efficacy and mechanisms of secondary resistance. Quality of life (QoL) related issues and panitumumab safety profile will be addressed as well.

Citations

Mar 25, 2020·American Society of Clinical Oncology Educational Book·Mohamed E SalemJeanne Tie
Feb 11, 2021·The Journal of Physical Chemistry. B·Klára SchulcBorbála M Kovács
Jun 6, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu-Chang LiuFei-Ting Hsu

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Methods Mentioned

BETA
biopsies
genotyping

Clinical Trials Mentioned

NCT00113763
NCT01412957
NCT01001377
NCT00364013
NCT00508404
NCT00819780
NCT00885885
NCT01328171
NCT00339183
NCT00418938

Software Mentioned

PRESSING
PRIME
VOLFI

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