The impact of paracentesis flow rate in patients with liver cirrhosis on the development of paracentesis induced circulatory dysfunction

Clinical and Molecular Hepatology
Maha Mohammad ElsabaawyEman Rewisha

Abstract

Ascites is a dreadful complication of liver cirrhosis associated with short survival. Large volume paracentesis (LVP) is used to treat tense or refractory ascites. Paracentesis induced circulatory dysfunction (PICD) develops if no plasma expanders are given with ominous complications. To study the effect of ascites flow rate on PICD development. Sixty patients with cirrhosis and tense ascites underwent LVP of 8 L were randomized into 3 equal groups of different flow rate extraction; group I (80 mL/minute), group II (180 mL/minute) and group III (270 mL/minute). Plasma renin activity (PRA) was measured baseline and on day six. PICD was defined as increase in PRA >50% of the pretreatment value. In group I through 3; the mean age was (52.5±9.4 vs. 56.4±8.5 vs. 55.8±7.1 years; P>0.05), mean arterial pressure (81.4±5.6 vs. 81.5±7 vs. 79.5±7.2 mmHg; P>0.05), MELD (17.6±4.1 vs. 15.8±4.1 vs. 14.7±4.5). Baseline PRA was comparable (1,366.0±1244.9 vs. 1,151.3±1,444.8 vs. 951.9±1,088 pg/mL; P>0.05). There was no statistically significant (P>0.05) flow mediated changes (Δ) of creatinine (0.23±0.27 vs. 0.38±0.33 vs. 0.26±0.18 mg/dL), MELD (1.25±5.72 vs. 1.70±2.18 vs. 1.45±2.21) or PRA (450.93±614.10 vs. 394.61±954.64 vs. 629.51±1,116.46 pg/...Continue Reading

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Citations

Apr 20, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J F CrismaleT D Schiano
Aug 1, 2018·Journal of Gastroenterology and Hepatology·Tae Hyung KimUNKNOWN Korean Study Group of Portal Hypertension
Jan 16, 2016·Clinical and Molecular Hepatology·Jeong Han Kim
Apr 11, 2020·Journal of Clinical and Translational Hepatology·Anand V KulkarniD Nageshwar Reddy
Aug 9, 2019·World Journal of Gastroenterology : WJG·Dmitry Victorovich Garbuzenko, Nikolay Olegovich Arefyev
Aug 5, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Tae Hyung KimUNKNOWN Korean Study Group of Portal Hypertension

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Methods Mentioned

BETA
urine collection
ELISA

Software Mentioned

SPSS

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