The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy

ELife
Laura A EwellJill K Leutgeb

Abstract

In epilepsy, brain networks generate pathological high-frequency oscillations (pHFOs) during interictal periods. To understand how pHFOs differ from normal oscillations in overlapping frequency bands and potentially perturb hippocampal processing, we performed high-density single unit and local field potential recordings from hippocampi of behaving rats with and without chronic epilepsy. In epileptic animals, we observed two types of co-occurring fast oscillations, which by comparison to control animals we could classify as 'ripple-like' or 'pHFO'. We compared their spectral characteristics, brain state dependence, and cellular participants. Strikingly, pHFO occurred irrespective of brain state, were associated with interictal spikes, engaged distinct subnetworks of principal neurons compared to ripple-like events, increased the sparsity of network activity, and initiated both general and immediate disruptions in spatial information coding. Taken together, our findings suggest that events that result in pHFOs have an immediate impact on memory processes, corroborating the need for proper classification of pHFOs to facilitate therapeutic interventions that selectively target pathological activity.

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Citations

Jul 7, 2020·Epilepsy Currents·Phillip L W Colmers, Jamie Maguire
Sep 19, 2019·Epilepsy Currents·Shyam Kumar Sudhakar, Omar J Ahmed
Jan 8, 2020·Nature Neuroscience·Tristan ShumanPeyman Golshani
Jan 4, 2021·Progress in Neurobiology·Aijaz Ahmad NaikJaideep Kapur
Feb 16, 2021·Frontiers in Human Neuroscience·Olivia N ArskiGeorge M Ibrahim
Oct 20, 2019·Behavioural Brain Research·Laetitia Chauvière
Jun 29, 2021·Revue neurologique·T Marissal

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