The impact of patient choice on survival in chronic thromboembolic pulmonary hypertension.

The European Respiratory Journal
Syed Rehan QuaderyD G Kiely

Abstract

Pulmonary endarterectomy (PEA) is the gold standard treatment for operable chronic thromboembolic pulmonary hypertension (CTEPH). However, a proportion of patients with operable disease decline surgery. There are currently no published data on this patient group. The aim of this study was to identify outcomes and prognostic factors in a large cohort of consecutive patients with CTEPH.Data were collected for consecutive, treatment-naive CTEPH patients at the Pulmonary Vascular Disease Unit of the Royal Hallamshire Hospital (Sheffield, UK) between 2001 and 2014.Of 550 CTEPH patients (mean±sd age 63±15 years, follow-up 4±3 years), 49% underwent surgery, 32% had technically operable disease and did not undergo surgery (including patient choice n=72 and unfit for surgery n=63), and 19% had inoperable disease due to disease distribution. The 5-year survival was superior in patients undergoing PEA (83%) versus technically operable disease who did not undergo surgery (53%) and inoperable due to disease distribution (59%) (p<0.001). Survival was superior in patients following PEA compared with those offered but declining surgery (55%) (p<0.001). In patients offered PEA, independent prognostic factors included mixed venous oxygen saturat...Continue Reading

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Citations

Sep 18, 2018·The European Respiratory Journal·Nick H Kim, Eckhard Mayer
Jan 12, 2019·The European Respiratory Journal·Nick H Kim, Eckhard Mayer
Jan 12, 2019·The European Respiratory Journal·Robin CondliffeDavid G Kiely
Sep 4, 2019·Journal of Thrombosis and Haemostasis : JTH·Stefano BarcoIrene M Lang
May 6, 2020·The European Respiratory Journal·Dieuwertje RuigrokHarm-Jan Bogaard
Apr 25, 2020·Frontiers in Cardiovascular Medicine·Florian LaschJens Vogel-Claussen
Nov 30, 2019·Journal of Thrombosis and Thrombolysis·Ran MiaoHuasong Feng
May 7, 2020·Frontiers in Medicine·A A Roger ThompsonAllan Lawrie
Feb 6, 2021·Clinics in Chest Medicine·Laura M PiechuraHari R Mallidi
Jan 30, 2021·Revista Española De Cardiología·Enric DomingoJuan Carlos Grignola
Jan 20, 2021·Respiratory Medicine·Hossein-Ardeschir GhofraniGérald Simonneau
May 6, 2021·Respiratory Research·T KoudstaalK A Boomars
Jun 19, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Mitchel J ColebankMette S Olufsen
Aug 20, 2021·Current Cardiology Reports·Yuri MatusovSudarshan Rajagopal
Jan 28, 2022·Expert Review of Cardiovascular Therapy·John E CannonStephen P Hoole

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Methods Mentioned

BETA
RAP

Clinical Trials Mentioned

NCT02565030

Software Mentioned

Prism
SPSS

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