The impact of patient-reported penicillin or cephalosporin allergy on surgical site infections.

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Jessica L SeidelmanSarah S Lewis

Abstract

To determine the impact of a documented penicillin or cephalosporin allergy on the development of surgical site infections (SSIs). Appropriate preoperative antibiotic prophylaxis reduces SSI risk, but documented antibiotic allergies influence the choice of prophylactic agents. Few studies have examined the relationship between a reported antibiotic allergy and risk of SSI and to what extent this relationship is modified by the antibiotic class given for prophylaxis. We conducted a retrospective cohort study of adult patients undergoing coronary artery bypass, craniotomy, spinal fusion, laminectomy, hip arthroplasty and knee arthroplasty at 3 hospitals from July 1, 2013, to December 31, 2017. We built a multivariable logistic regression model to calculate the adjusted odds ratio (aOR) of developing an SSI among patients with and without patient-reported penicillin or cephalosporin allergies. We also examined effect measure modification (EMM) to determine whether surgical prophylaxis affected the association between reported allergy and SSI. We analyzed 39,972 procedures; 1,689 (4.2%) with a documented patient penicillin or cephalosporin allergy, and 374 (0.9%) resulted in an SSI. Patients with a reported penicillin or cephalospo...Continue Reading

References

Nov 1, 1994·Journal of Clinical Epidemiology·M CharlsonJ Gold
Jun 6, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Mercedes E ArroligaAlejandro C Arroliga
May 19, 2011·Annals of Surgery·J Wesley AlexanderMichael J Edwards
May 15, 2013·Asia Pacific Allergy·Priyanka S Sagar, Constance H Katelaris
Oct 12, 2013·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sarah S LewisDeverick J Anderson
Nov 8, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Deverick J AndersonKeith S Kaye
Nov 12, 2015·Journal of the American Medical Informatics Association : JAMIA·Jaclynn M MoskowAngela S Garcia
Nov 18, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Christopher PoolBrett A Miles
Jan 24, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly G BlumenthalErica S Shenoy
Mar 5, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Andrea H StonePaul J King
Apr 10, 2020·The American Journal of Managed Care·Kimberly G BlumenthalRochelle P Walensky

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