Abstract
Systemic sclerosis (SSc) patients with gastrointestinal (GI) involvement have a lower quality of life (QoL) and while the impact of upper GI symptoms on QoL in SSc patients has been described few data exist on the presence and impact of lower gastrointestinal (LGI) and pelvic floor symptoms in SSc. Our goal was to assess the prevalence of these symptoms in women with SSc and evaluate their impact on QoL. A secondary hypothesis was that the impact of LGI symptoms on QoL is mediated by depression. Women with SSc (n=175) attending an outpatient scleroderma clinic completed multiple validated questionnaires. Pelvic floor and LGI symptoms included fecal incontinence (FI), urinary incontinence (UI), dual incontinence (DI), chronic constipation, diarrhea, and pelvic pain. The Student t tests adjusted for multiple comparisons were used to evaluate group differences at the 0.05 level. Complete data were available for 160 women. FI was reported by 65, UI by 64, DI by 40, chronic constipation by 94, diarrhea by 82, and pelvic pain by 35 of SSc patients. Overall QoL was reduced in SSc patients with FI (0.96 vs. 0.63; P=0.007), UI (0.96 vs. 0.65; P=0.01), DI (1.11 vs. 0.67; P=0.002), and pelvic pain (1.01 vs. 0.70; P=0.04). Antidepressant u...Continue Reading
References
Sep 1, 1994·Arthritis and Rheumatism·R W Sjogren
Dec 31, 1997·Journal of Clinical Gastroenterology·B W JaffinH Spiera
Jun 12, 1999·Scandinavian Journal of Gastroenterology·M TrezzaS Laurberg
Aug 9, 2003·Arthritis and Rheumatism·Maureen D MayesDavid Schottenfeld
Jun 2, 2006·Arthritis and Rheumatism·Angela E GliddonUNKNOWN Quins Trial Study Group
Aug 14, 2008·Behavior Research Methods·Kristopher J Preacher, Andrew F Hayes
Feb 13, 2009·European Journal of Gastroenterology & Hepatology·Karin Franck-LarssonAnders Rönnblom
Jun 12, 2009·Rheumatology·A Forbes, I Marie
Aug 29, 2009·Arthritis and Rheumatism·Dinesh KhannaDaniel E Furst
Oct 5, 2010·Rheumatology·Vijay BodukamDinesh Khanna
Feb 1, 2008·Current Treatment Options in Gastroenterology·Ellen C Ebert
Apr 21, 2011·Rheumatology·Nora M ThouaAnton V Emmanuel
Jul 20, 2011·Rheumatology International·T SchmeiserU Müller-Ladner
Oct 13, 2011·ISRN Gastroenterology·Hanaa S SallamJiande Z Chen
Nov 17, 2011·The American Journal of Gastroenterology·Nora M ThouaAnton V Emmanuel
Apr 3, 2012·The Journal of Rheumatology·Mohammed A Omair, Peter Lee
May 25, 2012·Arthritis Care & Research·Janet Pope
Citations
Sep 21, 2018·Current Opinion in Rheumatology·Zsuzsanna H McMahan, Laura K Hummers
Dec 6, 2019·The American Journal of Gastroenterology·Justin B BrandlerMichael Camilleri
Dec 26, 2016·Rheumatology·Nicolas RichardUNKNOWN on the behalf of Canadian Scleroderma Research Group
Oct 5, 2017·Rheumatology·Gregor JohnCarlo Chizzolini
Nov 23, 2017·United European Gastroenterology Journal·A GarrosF Mion
Oct 6, 2019·Rheumatology·Greta PaciniMaurizio Cutolo
Feb 26, 2021·Rheumatology International·Jamie BeringSarah B Umar