The Impact of Perioperative Antibiotic Prophylaxis on Weight Loss Following Laparoscopic Sleeve Gastrectomy.

Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a
Richard JacobsonPhilip Omotosho

Abstract

Although >10% of surgical patients receive alternative antibiotic prophylaxis for reported penicillin allergies, it is estimated that <20% of such cases represent true allergies that preclude standard prophylaxis. Each antibiotic class has a distinct impact on the intestinal microbiota and on postoperative metabolomics. The community structure and function of the microbiota are linked to the ability to lose weight after bariatric surgery. This study demonstrates differential weight loss after laparoscopic sleeve gastrectomy between patients who received standard (cefoxitin) and alternative (levofloxacin and metronidazole) perioperative prophylaxis. Multivariate analysis demonstrates that alternative prophylaxis is significantly and independently associated with diminished postoperative weight loss.

References

Nov 29, 2007·The ISME Journal·Cecilia JernbergJanet K Jansson
Aug 20, 2009·Surgical Endoscopy·Moisés JacobsRoberto Fogel
Jun 16, 2010·Expert Review of Pharmacoeconomics & Outcomes Research·Teena ChopraKeith S Kaye
Mar 7, 2013·Obesity Surgery·Juan Eduardo ContrerasJorge Bravo
Mar 11, 2017·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Cyrus JahansouzSayeed Ikramuddin
Jan 24, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kimberly G BlumenthalErica S Shenoy
Jun 15, 2018·Gut·Judith Aron-WisnewskyKarine Clément

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Citations

Mar 24, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Tammy L Kindel
Jul 22, 2021·Reviews in Endocrine & Metabolic Disorders·Carolina Gutiérrez-RepisoFrancisco J Tinahones

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Methods Mentioned

BETA
gastric bypass

Software Mentioned

R
GraphPad Prism

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