The Impact of Perioperative Use of a Statin-Magnesium Combination on Opioid Consumption in Patients Who Underwent Cardiac Surgery: A Retrospective Study with Propensity-Score Matching

Chonnam Medical Journal
Cheol Lee, Cheol Hwan So

Abstract

Both statins and magnesium are associated with NMDA receptors and anti-inflammatory effect. Peripheral NMDA receptors are known to be involved in inflammation-induced pain. This study aimed to investigate the impact of perioperative use of a statin-magnesium combination on opioid consumption in patients who underwent cardiac surgery. This was a retrospective study of 542 patients who underwent cardiac surgery. The patients were divided into two groups according to statin use: the statin-magnesium group (n=375) and the magnesium-only group (n=167). Patients in the magnesium-only group received only perioperative magnesium, but no statins, to prevent atrial fibrillation following cardiac surgery. After propensity-score matching, 228 patients (n=114 in each group) were analyzed to investigate opioid consumption, visual analogue scale (VAS) pain scores over a 72-h period, and pain outcomes according to the duration of statin treatment (<1 or ≥1 yr). The consumed opioid volume was significantly smaller in statin-magnesium group than the magnesium-only group, both before (p=0.010) and after matching (p=0.017). The statin-magnesium combination did not significantly reduce the VAS pain scores compared with magnesium alone. Although the...Continue Reading

References

Nov 26, 2008·Acta Anaesthesiologica Scandinavica·R FerasatkishM Z Totonchi
Mar 21, 2013·BMJ : British Medical Journal·Colin R DormuthUNKNOWN Canadian Network for Observational Drug Effect Studies
Oct 8, 2016·Annals of Cardiac Anaesthesia·Christian Ortega-LoubonEnrique Fulquet-Carreras
Nov 10, 2017·British Journal of Anaesthesia·J R SneydT Nightingale
Mar 30, 2018·Frontiers in Cardiovascular Medicine·Alexia HulinCécile Oury
Sep 11, 2018·Journal of Pain Research·Marek ZubrzyckiMaria Zubrzycka
Feb 1, 2019·Regional Anesthesia and Pain Medicine·Tak Kyu OhJung-Won Hwang

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Methods Mentioned

BETA
pharmacotherapy
coronary artery bypass
PCA

Software Mentioned

SPSS

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