The impact of pharmacy monitoring and intervention in patients receiving intravenous heparin

International Journal of Clinical Pharmacy
Michaela C LysogorskiRichard Geisler

Abstract

Background Intravenous unfractionated heparin (IV UFH) has a narrow therapeutic index and poses a high risk of bleeding. Objective To determine the impact of pharmacy monitoring and intervention on adherence to and appropriate implementation of IV UFH protocol. Setting A 438 bed hospital specializing in cardiac services. Methods This is a retrospective chart review study. Pre-pharmacy intervention data were collected from November 2013 to January 2014 and compared to post-pharmacy intervention data obtained between August 2014 and October 2014. Patients were included if they received IV UFH for at least 24 hours. The first three daytime laboratory draws were collected for each patient and analyzed using generalized estimating equations to quantify the association between pharmacy monitoring and adherence to the institution's protocol. Main outcome measures Designation of appropriate protocol, accurate selection of initial infusion rate, timing of anti-Xa levels within 60 min of anticipated due time, change of infusion rate within 120 min of laboratory result, and appropriate adjustment of infusion rates. Results A total of 195 data points were included. The initial selection of infusion rate and subsequent adjustments were more...Continue Reading

Associated Clinical Trials

References

Sep 1, 2004·Pharmacotherapy·Cynthia S NiccolaiUNKNOWN Heparin Consensus Group
May 10, 2006·Archives of Internal Medicine·Peter J KaboliJeffrey L Schnipper
May 8, 2008·The Annals of Pharmacotherapy·Paula J Biscup-HornKenneth M Shermock
Jul 29, 2008·American Heart Journal·Chiara MelloniUNKNOWN CRUSADE Investigators
Feb 23, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael L Smith, Kathryn E Wheeler
May 7, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jessica C WellmanMichael B Streiff
Nov 15, 2011·Journal of Thrombosis and Thrombolysis·Nancy L DawsonAlden V Patel
Dec 20, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Sara FowlerJames Tomsche
May 30, 2013·International Journal of Clinical Pharmacy·Subramaniam ThanimalaiJeyaindran Sinnadurai
Jun 12, 2013·Joint Commission Journal on Quality and Patient Safety·Ai Leng KhooTang Ching Lau
May 11, 2015·Research in Social & Administrative Pharmacy : RSAP·Manish MittalYu-Tze Ng
Aug 15, 2015·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Kristian S Frugé, Young R Lee

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Citations

Apr 26, 2019·Nursing·Chelsea LaughnerAmy Seitz Cooley

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