The Impact of Photoperiod on the Leptin Sensitivity and Course of Inflammation in the Anterior Pituitary.

International Journal of Molecular Sciences
Maciej WójcikAgata Krawczyńska

Abstract

Leptin has a modulatory impact on the course of inflammation, affecting the expression of proinflammatory cytokines and their receptors. Pathophysiological leptin resistance identified in humans occurs typically in sheep during the long-day photoperiod. This study aimed to determine the effect of the photoperiod with relation to the leptin-modulating action on the expression of the proinflammatory cytokines and their receptors in the anterior pituitary under physiological or acute inflammation. Two in vivo experiments were conducted on 24 blackface sheep per experiment in different photoperiods. The real-time PCR analysis for the expression of the genes IL1B, IL1R1, IL1R2, IL6, IL6R, IL6ST, TNF, TNFR1, and TNFR2 was performed. Expression of all examined genes, except IL1β and IL1R2, was higher during short days. The leptin injection increased the expression of all examined genes during short days. In short days the synergistic effect of lipopolysaccharide and leptin increased the expression of IL1B, IL1R1, IL1R2, IL6, TNF, and TNFR2, and decreased expression of IL6ST. This mechanism was inhibited during long days for the expression of IL1R1, IL6, IL6ST, and TNFR1. The obtained results suggest the occurrence of leptin resistance...Continue Reading

References

Jun 1, 1976·Endocrinology·R S SwerdloffG A Bray
Dec 1, 1989·Clinical Immunology and Immunopathology·M R ShalabyT Espevik
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y H ZhangJ Vilcek
Jul 1, 1987·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·T W KleinH Friedman
Feb 1, 1996·The New England Journal of Medicine·R V ConsidineT L Bauer
Jul 1, 1996·Endocrinology·I A BarashR A Steiner
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·W H YuS M McCann
Apr 1, 1997·Endocrine Reviews·D Ray, S Melmed
Feb 12, 1998·The American Journal of Physiology·R FaggioniC Grunfeld
Oct 24, 1998·Domestic Animal Endocrinology·U RennerG K Stalla
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B N Finck, R W Johnson
Oct 12, 2000·Cell Biology International·P IgazK Rácz
Feb 13, 2001·Neuroscience and Biobehavioral Reviews·C Rachal PughJ W Rudy
Mar 28, 2001·Annals of the New York Academy of Sciences·R J Nelson, D L Drazen
Jun 30, 2001·The Journal of Endocrinology·M MarieC L Adam
Feb 5, 2002·Pituitary·R V LloydB Burguera
Feb 5, 2002·Pituitary·V PopovicF F Casanueva
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Vera ChesnokovaShlomo Melmed
Jun 5, 2002·Annual Review of Biochemistry·Christian R H Raetz, Chris Whitfield
Apr 11, 2003·Reviews of Physiology, Biochemistry and Pharmacology·D KamimuraT Hirano
Oct 14, 2003·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Antonio La CavaGiuseppe Matarese
May 4, 2004·Nature Reviews. Immunology·Antonio La Cava, Giuseppe Matarese
Jul 29, 2004·Current Topics in Medicinal Chemistry·Klaus Brandenburg, Andre Wiese
Jan 12, 2005·FEBS Letters·Miguel OteroOreste Gualillo
Jan 12, 2005·Clinical and Diagnostic Laboratory Immunology·Shannon CopelandUNKNOWN Inflammation and the Host Response to Injury Investigators
Aug 25, 2006·Contributions to Nephrology·Graham M Lord
Mar 21, 2007·Journal of Dairy Science·P A AccorsiE Seren
Dec 29, 2007·The Journal of Pathology·J R Bradley
Oct 18, 2008·Journal of Neuroinflammation·Melissa K McCoy, Malú G Tansey
Oct 18, 2008·Journal of the American College of Cardiology·Seth S MartinMuredach P Reilly
May 5, 2009·Biochemical and Biophysical Research Communications·Norikazu KiguchiShiroh Kishioka

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Citations

Oct 21, 2020·International Journal of Molecular Sciences·Aleksandra SzczepkowskaJanina Skipor
Mar 3, 2021·Immunology Letters·Zhen WangJing Wei

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

STATISTICA
NormFinder

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