The Impact of Prehabilitation on Patient Outcomes in Hepatobiliary, Colorectal, and Upper Gastrointestinal Cancer Surgery: A PRISMA-Accordant Meta-analysis.

Annals of Surgery
Joel E LambertChristopher J Gaffney

Abstract

To determine the impact of prehabilitation on hospital length of stay, functional capacity, complications, and mortality after surgery in patients with hepatobiliary, colorectal, and upper gastrointestinal cancer. "Prehabilitation" encompasses exercise, nutrition, and psychosocial interventions to optimize health before surgery. The benefits of prehabilitation are ill-defined. Medline, Embase and Cochrane Databases were searched systematically for the terms "prehabilitation AND exercise," "perioperative care AND cancer surgery," and "colorectal AND hepatobiliary AND hepatopancreatobiliary AND esophagogastric AND recovery AND outcomes." Primary outcomes analyzed were hospital length of stay, functional capacity, significant postoperative complications (Clavien Dindo ≥ III), and mortality. A meta-analysis was conducted on the effect of all-modality prehabilitation for patients with colorectal, hepatopancreatobiliary and upper gastrointestinal cancer surgery using the raw mean difference, risk difference, and a random-effects model. Three hundred and seventy seven original titles were identified. Fifteen studies (randomized controlled trials; n = 9 and uncontrolled trials; n = 6) were included in the meta-analysis. Prehabilitation...Continue Reading

References

Jun 28, 2001·Medicine and Science in Sports and Exercise·C Bouchard, T Rankinen
Jan 25, 2003·Medicine and Science in Sports and Exercise·Gaelle KervioNathalie S Ville
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Luke Bi, George Triadafilopoulos
Oct 27, 2004·Journal of the American College of Surgeons·Valerie A LawrenceCarey P Page
Feb 21, 2006·Journal of the American College of Cardiology·Pedro Dall'AgoJorge P Ribeiro
Nov 9, 2007·Postgraduate Medical Journal·Khaled AlbouainiDavid Justin Wright
Feb 13, 2009·The Tohoku Journal of Experimental Medicine·Do Jun KimGerald S Zavorsky
May 26, 2009·The Australian Journal of Physiotherapy·Natalie A de Morton
Jul 30, 2009·Annals of Surgery·Pierre A ClavienMasatoshi Makuuchi
Jul 6, 2010·The British Journal of Surgery·F CarliN E Mayo
Dec 4, 2010·European Journal of Applied Physiology·Riggs J KlikaWilliam G Thorland
Jan 15, 2011·Acta Oncologica·Susanne Oksbjerg DaltonChristoffer Johansen
Sep 20, 2011·Best Practice & Research. Clinical Anaesthesiology·S JackM P W Grocott
Nov 6, 2012·American Journal of Surgery·Celeste Y KangSteven Mills
Mar 19, 2014·Medicine and Science in Sports and Exercise·Kerry S CourneyaJohn R Mackey
Jun 21, 2014·Surgery·Ioana AntonescuLiane S Feldman
Jan 4, 2015·BMJ : British Medical Journal·Larissa ShamseerUNKNOWN PRISMA-P Group
Oct 27, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C L K ChiaKok-Yang Tan
Nov 23, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Grace H HuangBernhard Riedel
Feb 13, 2016·The British Journal of Surgery·D F J DunneS W Fenwick
Aug 20, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Brian P ChenCelena Scheede-Bergdahl
Jan 10, 2017·Acta Oncologica·Francesco CarliCelena Scheede-Bergdahl
Jul 4, 2017·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M MazzolaG Ferrari
May 11, 2018·Medical Oncology·Michał PędziwiatrAndrzej Budzyński
Sep 17, 2018·Langenbeck's Archives of Surgery·Yuji KitahataHiroki Yamaue
Sep 30, 2018·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E T D SouwerJ W T Dekker
Feb 23, 2019·World Journal of Surgery·Michael J HughesRichard J E Skipworth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.