The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis.

Annals of Surgery
Alfred AdiamahDileep N Lobo

Abstract

To define the influence of preoperative immune modulating nutrition (IMN) on postoperative outcomes in patients undergoing surgery for gastrointestinal cancer. Although studies have shown that perioperative IMN may reduce postoperative infectious complications, many of these have included patients with benign and malignant disease, and the optimal timing of such an intervention is not clear. The Embase, Medline, and Cochrane databases were searched from 2000 to 2018, for prospective randomized controlled trials evaluating preoperative oral or enteral IMN in patients undergoing surgery for gastrointestinal cancer. The primary endpoint was the development of postoperative infectious complications. Secondary endpoints included postoperative noninfectious complications, length of stay, and up to 30-day mortality. The analysis was performed using RevMan v5.3 software. Sixteen studies reporting on 1387 patients (715 IMN group, 672 control group) were included. Six of the included studies reported on a mixed population of patients undergoing all gastrointestinal cancer surgery. Of the remaining, 4 investigated IMN in colorectal cancer surgery, 2 in pancreatic surgery, and another 2 in patients undergoing surgery for gastric cancer. Th...Continue Reading

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Citations

Jul 3, 2020·Pediatric Blood & Cancer·Caroline DiorioStacey Marjerrison
Oct 11, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Takehiro OkabayashiYasuhiro Shimada
Jul 3, 2020·Langenbeck's Archives of Surgery·Kosei TakagiToshiyoshi Fujiwara
Feb 19, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hu Qiang, Yu Binying
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Nov 21, 2019·The British Journal of Surgery
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Dec 7, 2020·The Journal of Surgical Research·Jia Jun AngDedrick Kok Hong Chan
Feb 4, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Junjie WangGuohao Wu
Apr 8, 2021·Annals of Surgical Oncology·Yinin HuVivian E Strong
Apr 15, 2021·Current Opinion in Anaesthesiology·Ibukunoluwa Adeleke, Jeanna Blitz
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Aug 31, 2021·International Anesthesiology Clinics·Sher-Lu PaiR Doris Wang
Jan 7, 2022·Expert Review of Anticancer Therapy·Gabriele CapursoMichele Reni

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