The impact of preoperative nutritional status on post-surgical complication and mortality rates in patients undergoing radical cystectomy for bladder cancer: a systematic review of the literature.

World Journal of Urology
Paola Irene OrnaghiMarco Moschini

Abstract

To investigate the impact of preoperative nutritional factors [body mass index (BMI)], hypoalbuminemia (< 3.5 g/dL, sarcopenia) on complication and mortality rates after radical cystectomy (RC) for bladder cancer. The PubMed database was systematically searched for studies investigating the effect of nutritional status on postoperative outcomes after RC. English-language articles published between March 2010 and March 2020 were reviewed. For statistical analyses odds ratios (ORs) and hazard ratios (HRs) weighted mean was applied. Overall, 81 studies were included. Twenty-nine studies were enrolled in the final analyses. Patients with a 25-29.9 kg/m2 BMI (OR 1.55, 95% confidence interval [CI] 1.14-2.07) and those with a BMI ≥ 30 kg/m2 (OR 1.73, 95% CI 1.29-2.40) had a significantly increased risk of 30 day complications after RC. Preoperative hypoalbuminemia increased the risk of 30 day complications (OR 1.56, 95% CI 1.07-2.35); it was a predictor of worse 3 year overall survival (OS) (HR 1.86, 95% CI 1.32-2.66). Sarcopenic patients had a higher risk of 90 day complications than non-sarcopenic ones (OR 2.49, 95% CI 1.22-5.04). Sarcopenia was significantly associated with unfavorable 5 year cancer-specific survival (CSS) (HR 1.73...Continue Reading

References

Jul 30, 2009·Annals of Surgery·Pierre A ClavienMasatoshi Makuuchi
Nov 16, 2010·The Journal of Urology·Justin R GreggDaniel A Barocas
Jun 26, 2012·BJU International·Thomas F ChromeckiShahrokh F Shariat
Jul 4, 2013·The Journal of Urology·Yannick CerantolaPatrice Jichlinski
Jul 11, 2013·European Journal of Clinical Nutrition·B T JensenM Borre
Aug 3, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Florian RoghmannJüri Palisaar
Oct 4, 2013·Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi·S ChanH Chiu
Nov 22, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Mark D TysonErik P Castle
Jan 5, 2014·The Journal of Urology·Timothy F DonahueHebert A Vargas
Jan 16, 2014·The Journal of Urology·Angela B SmithMatthew E Nielsen
Apr 10, 2014·Clinical Genitourinary Cancer·Francesco CantielloRocco Damiano
Sep 23, 2014·World Journal of Urology·David C JohnsonAngela B Smith
Nov 20, 2014·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Giorgio GandagliaQuoc-Dien Trinh
Mar 12, 2016·Arab Journal of Urology·Katie M MurrayEugene K Lee

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Citations

Jul 13, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yisi D Ji, Thomas B Dodson

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