The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children

European Journal of Nutrition
Sanna VähämikoKirsi Laitinen

Abstract

Dietary supplementation with probiotics during pregnancy has been suggested to decrease the risk for obesity in women after delivery and to minimize excessive weight gain in their children. Epigenetic DNA methylation has been proposed to impact on gene activity, thereby providing a plausible molecular mechanism for a broad range of biological processes and diseases. This pilot study aimed to evaluate whether probiotic supplementation during pregnancy could modify the DNA methylation status of the promoters of obesity and weight gain-related genes in mothers and their children. A sample of 15 pregnant women was taken from a prospective, randomized mother and infant nutrition and probiotic study. Seven women received the probiotic supplementation and eight served as controls. The women's and their children's DNA methylation status of obesity (623 genes) and weight gain-related (433) gene promoters were analyzed from blood samples at the mean of 9.8 months (range 6.1-12.7 months) postpartum. Probiotic supplementation led to significantly decreased levels of DNA methylation in 37 gene promoters and increased levels of DNA methylation in one gene promoter in women. In their children, 68 gene promoters were significantly affected con...Continue Reading

References

Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Sep 9, 1989·Lancet·D J BarkerS J Simmonds
Sep 28, 2005·Current Microbiology·Esther JiménezJuan M Rodríguez
Dec 22, 2006·The British Journal of Nutrition·T PiirainenK Laitinen
Nov 20, 2008·The British Journal of Nutrition·Kirsi LaitinenUNKNOWN Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota Group
Nov 21, 2008·Letters in Applied Microbiology·R SatokariE Isolauri
Dec 31, 2009·Current Opinion in Gastroenterology·Petr HruzLars Eckmann
Mar 6, 2010·Science·Matam Vijay-KumarAndrew T Gewirtz
Mar 17, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R LuotoE Isolauri
Oct 13, 2010·Cardiovascular Diabetology·Enrique Z Fisman, Alexander Tenenbaum
Oct 26, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Johanna IlmonenKirsi Laitinen
Jan 8, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Maria KoutsakiDemetrios A Spandidos
Sep 3, 2011·Science·Gary D WuJames D Lewis
Aug 9, 2012·European Journal of Human Genetics : EJHG·Tea BerulavaBernhard Horsthemke
Sep 14, 2012·Journal of Clinical Gastroenterology·Enrico IemoliLorenzo Drago
Sep 26, 2012·Nature Neuroscience·Giles S H Yeo, Lora K Heisler
Oct 24, 2012·Free Radical Biology & Medicine·Jennalynn StyskalAdam B Salmon
Jan 2, 2013·Trends in Cell Biology·Henriette KirchnerJuleen R Zierath
Jan 31, 2013·Annals of Internal Medicine·Bradley C JohnstonGordon H Guyatt
Mar 12, 2013·Journal of Pregnancy·Bonnie BrensekeJ Claudio Gutierrez
Mar 27, 2013·Nature Reviews. Endocrinology·Julia S El-Sayed Moustafa, Philippe Froguel
May 11, 2013·Molecular Nutrition & Food Research·Melissa B GlierAngela M Devlin
Jun 19, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L FaniE L T van den Akker
Oct 30, 2013·Nutrition Reviews·Elena Zambrano, Peter W Nathanielsz
Oct 30, 2013·Nutrition Reviews·Adolfo Correa, Jessica Marcinkevage
Nov 15, 2013·Annals of Nutrition & Metabolism·R LuotoE Isolauri
Nov 30, 2013·Applied Microbiology and Biotechnology·Diana Di GioiaBruno Biavati
Jan 5, 2014·Molecular Biology Reports·Vita RoviteJanis Klovins
Jan 21, 2014·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Brett M Jakaitis, Patricia W Denning
Aug 20, 2015·The New England Journal of Medicine·Melina ClaussnitzerManolis Kellis
Feb 26, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Rene CorteseErika C Claud
Jun 1, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y ZhouC S McLachlan

❮ Previous
Next ❯

Citations

Mar 10, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Anna ForsbergMaria C Jenmalm
Jun 12, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Béatrice S-Y ChoiAngelo Tremblay
Feb 6, 2020·Frontiers in Genetics·Manvi SharmaTrygve O Tollefsbol
Nov 5, 2020·The British Journal of Nutrition·Outi PellonperäKirsi Laitinen
Apr 17, 2021·Environmental Science and Pollution Research International·Amr El-SayedMohamed Kamel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
L B van der AaW M C van Aalderen
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A HuurreErika Isolauri
© 2022 Meta ULC. All rights reserved