The impact of probiotics' administration on glycemic control, body composition, gut microbiome, mitochondria, and other hormonal signals in adolescents with prediabetes - A randomized, controlled trial study protocol

Contemporary Clinical Trials Communications
Charikleia StefanakiAthanasios Michos

Abstract

Recent studies have demonstrated that a significant proportion of adolescents exhibit abdominal obesity in early-middle adolescence, and impaired glucose metabolism. Dysregulation of glucose metabolism is aggravated by the existing osteosarcopenia not only in obese but also in overweight youth. Biochemical inflammation, derived from glucose metabolism dysregulation, in combination with increased stress levels lead to the accumulation of reactive oxygen species, also known as ROS, which seem to afflict the integrity of the gastrointestinal wall, gut mucosa, and commensal, intestinal gut microflora. The current scientific protocol aims to assess the administration of probiotics in prediabetic adolescents in relation with their glycemic control, body composition, and intestinal microbiome. This is a study protocol of a two-armed RCT, that recruits adolescents with prediabetes, who will receive either a 4-month, life-style intervention, or a life-style intervention along with a probiotic supplement. The primary outcome is the differences in gut microbiome synthesis, body composition analysis parameters, and concentrations of hormones, before and after the intervention. This study aims to halt the progression of obesity and diabetes...Continue Reading

Citations

Aug 7, 2019·Journal of Cellular Biochemistry·Jiezhong Chen, Luis Vitetta
Oct 24, 2019·Journal of Clinical Medicine·Charikleia StefanakiFlora Bacopoulou
Jan 15, 2022·Probiotics and Antimicrobial Proteins·Evgeniya V PrazdnovaMichael L Chikindas

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Methods Mentioned

BETA
PCR

Software Mentioned

StatSoft Statistica
Vivomixx
Visbiome
MOTS

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