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The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Nature Genetics

Nov 1, 2019

Mireia Ramos-RodríguezLorenzo Pasquali

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Abstract

The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokines reveals a marked plasticity of the β-cell regulatory landscape. We expand th...read more

Mentioned in this Paper

Autoimmunity
Diabetes Mellitus, Insulin-Dependent
Environment
Genes, Regulator
Insulin
Islets of Langerhans
Structure of Beta Cell of Islet
Regulatory Sequences, Nucleic Acid
Regulatory T-Lymphocytes
Transcription Factor
146
3
27
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The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Nature Genetics

Nov 1, 2019

Mireia Ramos-RodríguezLorenzo Pasquali

PMID: 31676868

DOI: 10.1038/s41588-019-0524-6

Abstract

The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokines reveals a marked plasticity of the β-cell regulatory landscape. We expand th...read more

Mentioned in this Paper

Autoimmunity
Diabetes Mellitus, Insulin-Dependent
Environment
Genes, Regulator
Insulin
146
3
27

Similar Papers Found In These Feeds

Paper Details
References
  • References78
  • Citations
12345...
  • References78
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

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