The impact of proton pump inhibitors on the intestinal microbiota in chronic hepatitis C patients

Scandinavian Journal of Gastroenterology
Freya WellhönerBenjamin Heidrich

Abstract

Objectives: Proton pump inhibitors (PPI), a class of drugs commonly used, are known to be associated with changes in the intestinal microbiota. Published studies were done in heterogeneous cohorts which could hamper conclusions drawn as effects of diseases were not taken into consideration. We aimed to elucidate differences in the intestinal microbiota being associated to the use of PPI in a cohort study of patients with chronic hepatitis C. Material and Methods: The 16S rDNA gene was analyzed in stool samples of patients with and without PPI use. Patients with concomitant medication influencing the microbiota were excluded. Results were compared with the clinical course of hepatitis C patients with decompensated liver cirrhosis. Results: No differences in alpha diversity could be observed, while the microbial community structure differed significantly, especially in patients with liver cirrhosis. The relative abundance of Streptococcus spp., Enterobacter spp. and Haemophilus spp. was significantly increased in patients with PPI use irrespectively of the stage of liver disease. Finally, in patients with decompensated liver cirrhosis due to chronic HCV infection only in these using PPI bacterial phylotypes were isolated. Conclus...Continue Reading

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Citations

Jan 17, 2021·Biology·Mohammed El-MowafyWalid Mottawea
Oct 30, 2020·ACS Infectious Diseases·Salma SultanWalid Mottawea
Jan 8, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Freya WellhönerBenjamin Heidrich
Jul 7, 2021·Expert Review of Molecular Diagnostics·Quentin Le BastardEmmanuel Montassier
Aug 20, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Takako InoueYasuhito Tanaka

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