The impact of psychogenic stressors on oxidative stress markers and patterns of CYP2E1 expression in mice liver

Pathophysiology : the Official Journal of the International Society for Pathophysiology
Oksana Maksymchuk, Mykola Chashchyn

Abstract

The increasing number of psychogenic stressors is a side effect of civilization. It results in the development of psychoemotional stresses and psychosomatic diseases. In this study we evaluated the effect of the chronic psychoemotional stress on the level of CYP2E1 expression in the liver of C57Bl/6 mice. Stress was induced by the immobilization of animals for 4h per day during 7 or 14 days. CYP2E1 expression level was evaluated on the 7th and 14th days of the experiment, respectively. We detected a twofold reduction in CYP2E1 protein expression level relatively to controls for both time points tested. This reduction was no longer significant when the effect of the stressor factor was terminated on the 14th day of the experiment and animals were analyzed one week later. Remarkably Cyp2e1 mRNA expression level was constant at any time point of the experiment. We also documented significant changes in the expression/activity of two oxidative stress markers examined in the liver of treated mice. The catalase activity decreased fivefold while malondialdehyde transiently increased threefold. These data suggest that oxidative stress can be involved in the reduction of hepatic CYP2E1 and catalase activity under the conditions of chron...Continue Reading

References

Jul 5, 2001·Cellular and Molecular Life Sciences : CMLS·P Anzenbacher, E Anzenbacherová
Oct 30, 2004·Journal of Toxicology and Environmental Health. Part a·Dal Woong ChoiGerard Siest
Feb 8, 2006·Journal of Gastroenterology and Hepatology·Yoichi ChidaChiharu Kubo
May 19, 2009·Archives of Toxicology·Arthur I CederbaumDefeng Wu
Jun 26, 2009·World Journal of Gastroenterology : WJG·Cristin Constantin VereFelix Sima
Apr 26, 2011·Lipids in Health and Disease·Wafa MarouaneAbdelfattah El Feki

Citations

Apr 22, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Cécile GurnotTakao K Hensch
Sep 16, 2016·Cell Biology International·Tetiana KochubeiLyubov Lukash
May 19, 2017·Animal : an International Journal of Animal Bioscience·E HeyrmanM Aluwé
Aug 6, 2019·Pharmacological Reports : PR·Oksana Maksymchuk, Vladimir Kashuba

Related Concepts

Biological Markers
Catalase
General Adaptation Syndrome
Liver
Malondialdehyde
Laboratory mice
Psychophysiologic Disorders
RNA, Messenger
Emotional Stress
Hepatic

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