The Impact of Psychological Stress on Mast Cells

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Theoharis C Theoharides

Abstract

Atopic diseases worsen with psychological stress, but how stress contributes to their pathogenesis is still not clear. We review the evidence supporting the premise that stress contributes to allergic and inflammatory processes via stimulation of mast cells (MC) by neuroimmune stimuli. Pubmed was searched between 1950-2019 using the terms allergies, atopic diseases, corticotropin-releasing hormone, inflammation, hypothalamic-pituitary-adrenal axis, mast cells, mastocytosis, neuropeptides, psychological stress, neurotensin, substance P. Only papers published in English were selected based on their relevance to stress and mast cells, especially those that discussed potential mechanisms of action. Psychological stress worsens many diseases, especially asthma and atopic dermatitis (AD) and mastocytosis. This effect is mediated via MC stimulated by neuropeptides, especially corticotropin-releasing hormone (CRH), neurotensin (NT) and substance (SP), a process augmented by IL-33. Understanding how stress stimulates MC to release pro-inflammatory mediators is important in advancing treatments for diseases that worsen with stress.

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Citations

Dec 29, 2020·Experimental Dermatology·Amos GilharRalf Paus
Apr 4, 2021·International Journal of Molecular Sciences·Mika Yamanaka-TakaichiDaisuke Tsuruta
Apr 14, 2021·BioFactors·Theoharis C TheoharidesAntonios Politis
Apr 16, 2021·The Journal of Allergy and Clinical Immunology·Kimberly A RismaJoshua D Milner
May 9, 2021·Experimental Dermatology·Yue ZhangJianyun Lu
Jul 10, 2021·Chaos·Maria Elena Gonzalez Herrero, Christian Kuehn

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