The Impact of Psychological Stress on Mast Cells
Abstract
Atopic diseases worsen with psychological stress, but how stress contributes to their pathogenesis is still not clear. We review the evidence supporting the premise that stress contributes to allergic and inflammatory processes via stimulation of mast cells (MC) by neuroimmune stimuli. Pubmed was searched between 1950-2019 using the terms allergies, atopic diseases, corticotropin-releasing hormone, inflammation, hypothalamic-pituitary-adrenal axis, mast cells, mastocytosis, neuropeptides, psychological stress, neurotensin, substance P. Only papers published in English were selected based on their relevance to stress and mast cells, especially those that discussed potential mechanisms of action. Psychological stress worsens many diseases, especially asthma and atopic dermatitis (AD) and mastocytosis. This effect is mediated via MC stimulated by neuropeptides, especially corticotropin-releasing hormone (CRH), neurotensin (NT) and substance (SP), a process augmented by IL-33. Understanding how stress stimulates MC to release pro-inflammatory mediators is important in advancing treatments for diseases that worsen with stress.
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