The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases

Journal of Immunology Research
Margarete BagatiniFabiano Barbosa Carvalho

Abstract

Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases. These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually leading to tissue or organ degeneration. These pathological conditions can be associated with disturbance in the signaling mediated by nucleotides and nucleosides of adenine, in expression or activity of extracellular ectonucleotidases and in activation of P2X and P2Y receptors. Among the best known of these diseases are atherosclerosis, hypertension, cancer, epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). The currently available treatments present limited effectiveness and are mostly palliative. This review aims to present the role of purinergic signaling highlighting the ectonucleotidases E-NTPDase, E-NPP, E-5'-nucleotidase, and adenosine deaminase in noncommunicable, neurological, and degenerative diseases associated with the cardiovascular and central nervous systems and cancer. In conclusion, changes in the activity of ectonucleotidases were verified in all reviewed diseases. Although th...Continue Reading

References

Dec 1, 1992·Brain : a Journal of Neurology·H ChristensenG A Broe
Jan 1, 1991·Annals of the New York Academy of Sciences·K A WesnesK Siegfried
Jan 1, 1985·General Pharmacology·G Burnstock, C Kennedy
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Jan 1, 1994·Pharmacology & Therapeutics·M P Abbracchio, G Burnstock
Mar 1, 1996·Journal of Neuropathology and Experimental Neurology·L S Forno
May 30, 1998·Clinical and Experimental Hypertension : CHE·S P TofovicE K Jackson
Feb 1, 2000·Molecular Medicine Today·R GoldK V Toyka
Feb 28, 2002·British Journal of Pharmacology·Francesco Di Virgilio, Anna Solini
Feb 11, 2003·Progress in Neurobiology·J A RibeiroA de Mendonça
Jan 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Cuiling LiuXiaoqiang Yao
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shigeki TsutsuiChristopher Power
Nov 19, 2004·International Review of Cytology·Geoffrey Burnstock, Gillian E Knight
Jan 20, 2005·The Journal of Biological Chemistry·Nelson P BarreraJ Michael Edwardson
Feb 11, 2005·Molecular Pharmacology·Joel Linden
May 11, 2005·Drug News & Perspectives·Laszlo KölesPeter Illes
Jul 16, 2005·Neurochemical Research·Rafael NicolaidisDiogo Onofre Souza
Jan 19, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bronwen A J EvansJack Ham
Feb 17, 2006·Neurobiology of Aging·Charles G Glabe
Feb 21, 2006·Trends in Pharmacological Sciences·Geoffrey Burnstock
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lanfen Chen, Celia F Brosnan
Mar 2, 2006·Pharmacological Reviews·Geoffrey Burnstock
Mar 7, 2006·Nature Reviews. Drug Discovery·Kenneth A Jacobson, Zhan-Guo Gao
May 23, 2006·Nature Reviews. Neuroscience·R Douglas Fields, Geoffrey Burnstock
Aug 11, 2006·Annals of Tropical Medicine and Parasitology·A D Lopez, C D Mathers
Aug 18, 2006·FEBS Letters·Alberto Gómez-RamosJesús Avila
Aug 19, 2006·Arquivos de neuro-psiquiatria·Eduardo Fernandes BondanDominguita Luhers Graça

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Citations

May 7, 2019·Frontiers in Cellular Neuroscience·Natalie RotermundChristian Lohr
Mar 15, 2020·Purinergic Signalling·Marta Schmidt PfaffenzellerAndréia Machado Cardoso
Dec 29, 2020·Journal of Food Biochemistry·Veronica F SalauMd Shahidul Islam
Apr 22, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clarissa Branco HaasGyörgy Haskó
Jun 16, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ochuko L ErukainureMd Shahidul Islam
Nov 19, 2019·Journal of Medicinal Chemistry·Maria João MatosFernanda Borges
Nov 7, 2021·Purinergic Signalling·Gilnei Bruno da SilvaMargarete Dulce Bagatini

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