PMID: 11310307Apr 20, 2001Paper

The impact of QT lag compensation on dynamic assessment of ventricular repolarization: reproducibility and the impact of lead selection

Pacing and Clinical Electrophysiology : PACE
Christopher C E LangJ M Neilson

Abstract

In cardiac disease, abnormalities exist in the rate-corrected QT interval and the relationship between QT and heart rate. The QT/RR relationship is known to be dynamic and show circadian variation. The availability of automated methods for measurement of QT and RR intervals allows monitoring of the QT/RR relationship and may provide insights into arrhythmia onset. Using a method for analyzing 24-hour recordings that incorporates beat-by-beat QT and RR measurement and an automated mechanism for compensating for lag in adaptation of QT to changes in RR, the authors evaluated the impact of lag compensation on assessment of the QT/RR relationship, reproducibility, and the effect of lead selection in 15 normal subjects. The QT/RR relationship is continuously estimated from the lag compensated data over a 5-minute scrolling time frame. The relationship is expressed as an exponential formula, QT = QTo.RRJ where QTo is the QT interval at a standardized RR interval of 1 second and J is a variable exponent. We found that the use of lag compensation significantly improves the mean 24-hour correlation between QT and RR data (r = 0.87 vs 0.65). The 24-hour mean of QTo and J were highly reproducible (coefficients of variation 2% and 8%, resp...Continue Reading

Citations

Jun 2, 2011·Journal of Biological Physics·Tomofumi KimotsukiMari Alford Watanabe
Feb 3, 2005·Pacing and Clinical Electrophysiology : PACE·Beata SredniawaLech Polonski
May 1, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Daniel J PelchovitzJeffrey J Goldberger
Aug 7, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Mari A Watanabe
Nov 18, 2004·Pacing and Clinical Electrophysiology : PACE·Christopher LangJames Neilson
Jul 13, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Dayimi KayaCetin Dincel
Jul 13, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Christopher C E LangAndrew D Flapan
Jun 11, 2004·Pacing and Clinical Electrophysiology : PACE·Beata SredniawaLech Polonski
Jan 21, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Berit T JensenJørgen K Kanters
Jul 31, 2008·Journal of Cardiovascular Electrophysiology·Prince J KannankerilDan M Roden
Jun 17, 2006·Journal of Electrocardiology·Marc R DweckAndrew D Flapan
Jan 25, 2019·Canadian Journal of Physiology and Pharmacology·Antoinette Oliveira BlackmanOtoni Moreira Gomes
Oct 14, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Marek MalikGeorg Schmidt
Jul 22, 2018·Brain and Behavior·Ksenija CankarVito Starc

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