The impact of recurrent acute chest syndrome on the lung function of young adults with sickle cell disease.

Lung
Jennifer Knight-MaddenAnne Greenough

Abstract

The aim of this study was to assess the impact of recurrent acute chest syndrome (ACS) episodes on the lung function of young adults with sickle cell disease (SCD). Our prospective study included 80 SCD adults [26 with recurrent acute chest syndrome (ACS)] and 80 ethnically matched controls aged between 18 and 28 years. Lung function (spirometry and lung volumes) was measured and the results were expressed as the percentage predicted for height. Bronchial hyperresponsiveness (BHR) was assessed by the response to either a bronchodilator or an exercise challenge. The adults with recurrent ACS (two or more ACS episodes) had lower median forced vital capacity (74 vs. 83%, p = 0.03), forced expiratory volume in 1 s (79 vs. 90%, p < 0.03), and total lung capacity (69 vs. 81%, p = 0.04) than SCD adults who had one or no ACS episodes. The greater the number of ACS episodes, the greater the reduction in lung function (p = 0.001). The adults with SCD had lower median forced vital capacity (81 vs. 106%), forced expiratory volume in 1 s (85 vs. 107%), and total lung capacity (80 vs. 87%) than the controls (p < 0.001). Similar numbers in each group had BHR (p = 0.2). The prevalence of restrictive ventilatory defect in the patients with SCD ...Continue Reading

References

Jul 1, 1972·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·G J MillerA Ashworth
Sep 1, 1993·Blood Reviews·G R Serjeant, B E Serjeant
Dec 24, 1998·The European Respiratory Journal·F SantoliG Atlan
Mar 25, 2006·American Journal of Respiratory and Critical Care Medicine·Elizabeth S KlingsMartin H Steinberg
Aug 16, 2006·The American Journal of the Medical Sciences·Elisa Cristina VendraminiJoão Terra-Filho
Mar 24, 2007·American Journal of Respiratory and Critical Care Medicine·Anastasia AnthiMark T Gladwin
May 1, 2007·Pediatric Pulmonology·Anastassios C KoumbourlisAda Lee
May 26, 2007·The American Journal of Forensic Medicine and Pathology·Jason K GrahamMario Mosunjac
Apr 11, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chang-Hoon LeeHyun-Woo Han
Jul 16, 2008·The American Journal of the Medical Sciences·Elcio Oliveira ViannaAntônio Augusto Moura Da Silva
Aug 2, 2008·Pediatric Pulmonology·Robert C StrunkMichael R DeBaun
Sep 9, 2008·American Journal of Respiratory and Critical Care Medicine·Joanna E MacLeanPadmaja Subbarao

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Citations

Jul 6, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·J CookJ Rylance
Nov 28, 2013·Paediatric Respiratory Reviews·Jennifer Knight-Madden, Anne Greenough
Oct 7, 2011·Hemoglobin·Ruby A KhouryMiguel R Abboud
Oct 1, 2011·Expert Review of Respiratory Medicine·Samuel O AnimMichael R DeBaun
Dec 24, 2015·Pediatric Pulmonology·Alan LuntAnne Greenough
Apr 9, 2013·European Journal of Haematology·Rabindra PaulVictor R Gordeuk
May 28, 2011·European Journal of Haematology·Rabindra N PaulPatricia A Oneal
Feb 3, 2016·Chest·Enrico M Novelli, Mark T Gladwin
Apr 1, 2015·British Journal of Haematology·Jo HowardUNKNOWN BCSH Committee
Dec 11, 2013·BioMed Research International·Esteban Gomez, Claudia R Morris
Feb 3, 2016·Chest·Alem Mehari, Elizabeth S Klings
Jun 15, 2016·Annals of the American Thoracic Society·Robyn T CohenMichael R DeBaun
Mar 2, 2017·American Journal of Respiratory and Critical Care Medicine·Anya McLarenHartmut Grasemann
Apr 6, 2017·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Roberta Pulcheri Ramos
Apr 13, 2018·Hospital Practice·Sajid FarooqGary A Salzman
Oct 18, 2018·Annual Review of Pathology·Prithu SunddEnrico M Novelli
May 29, 2020·Pediatric Pulmonology·Mohammed Al BiltagiNermin Kamal Saeed
May 7, 2019·Advances in Hematology·Yvonne A Dei-AdomakohJoseph K Acquaye
Aug 19, 2017·Scientific Reports·Jun RenJoanna E MacLean
Apr 23, 2021·Journal of Pediatric Hematology/oncology·Aliva DeMargaret T Lee

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