The impact of regulatory action on the co-prescribing of renin-angiotensin system blockers in UK primary care

Pharmacoepidemiology and Drug Safety
Craig Allen, Katherine Donegan

Abstract

The aim of this study was to assess the impact of regulatory action taken in June 2014 on the co-prescribing of renin-angiotensin system (RAS) blockers in UK primary care. RAS blocker prescriptions, issued between 01/01/2009-30/06/2015, were extracted from the Clinical Practice Research Datalink to estimate the quarterly prevalence (number of patients with at least one co-prescription) and incidence (number of patients first receiving a RAS blocker co-prescription) of co-prescribing. Two different RAS blockers prescribed on the same day constituted a co-prescription. A total of 880 364 patients were prescribed a single RAS blocker during the study period. Prevalence of co-prescribing increased from 4812 patients per million person-years in Q1 2009 to 4865 in Q1 2010. A reduction then occurred decreasing to 2901 patients per million person-years in Q2 2014 when the EU review concluded and continued to decrease thereafter despite a continued increase in the prevalence of prescribing of a single RAS blocker. Incidence of new co-prescribing decreased from 454 patients per million person-years in Q1 2009 to 159 in Q2 2014, but remained relatively constant at ~119 patients per million person-years on average after the EU review concl...Continue Reading

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Citations

Jul 10, 2019·Journal of Clinical Pharmacy and Therapeutics·Takuya ImatohYoshiro Saito
Feb 6, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Andrea M RussellMeredith Y Smith

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