The impact of revascularization on myocardial blood flow as assessed by positron emission tomography

European Journal of Nuclear Medicine and Molecular Imaging
Robert M BoberDaniel P Morin

Abstract

Revascularization aims to improve myocardial perfusion. However, changes in regional artery-specific quantitative perfusion after revascularization have not been systematically investigated. It is unclear whether artery-specific thresholds for coronary flow capacity (CFC) and/or relative perfusion predict improved stress perfusion after revascularization. We sought to determine the impact of revascularization based on predefined, artery-specific, severity size thresholds for CFC and/or relative perfusion defects. Fifty patients underwent PET imaging before revascularization and then prospectively within 90 days after revascularization. Changes in regional myocardial blood flow (MBF) were stratified based on baseline perfusion abnormalities, baseline reduced CFC, and whether revascularization was performed in that region. Following angiographic stenosis-directed revascularization, in regions with relative perfusion abnormalities and decreased CFC, stress MBF (sMBF) increased by 0.51 cm3/min/g (59%) from baseline (p < 0.001). In regions without baseline perfusion abnormalities and yet decreased CFC, sMBF increased by 0.35 cm3/min/g (40%) from baseline (p < 0.001). In regions without perfusion abnormalities and normal CFC, sMBF di...Continue Reading

References

Mar 28, 2007·The New England Journal of Medicine·William E BodenUNKNOWN COURAGE Trial Research Group
Jan 16, 2009·The New England Journal of Medicine·Pim A L ToninoUNKNOWN FAME Study Investigators
Aug 29, 2012·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators
Mar 30, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Robert M BoberDaniel P Morin

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Citations

Jun 4, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Alexia Rossi, Giuseppe Ferrante
Apr 17, 2020·Journal of Cardiovascular Electrophysiology·Peter G PantlinDaniel P Morin
May 18, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Christel H Kamani, John Prior
Apr 3, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Matthieu Pelletier-Galarneau, Terrence D Ruddy
Feb 2, 2022·European Heart Journal Cardiovascular Imaging·Teemu MaaniittyAntti Saraste

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Methods Mentioned

BETA
coronary artery bypass

Clinical Trials Mentioned

NCT02931331

Software Mentioned

SPSS
Revasc

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