The impact of robustness of deformable image registration on contour propagation and dose accumulation for head and neck adaptive radiotherapy

Journal of Applied Clinical Medical Physics
Lian ZhangX George Xu

Abstract

Deformable image registration (DIR) is the key process for contour propagation and dose accumulation in adaptive radiation therapy (ART). However, currently, ART suffers from a lack of understanding of "robustness" of the process involving the image contour based on DIR and subsequent dose variations caused by algorithm itself and the presetting parameters. The purpose of this research is to evaluate the DIR caused variations for contour propagation and dose accumulation during ART using the RayStation treatment planning system. Ten head and neck cancer patients were selected for retrospective studies. Contours were performed by a single radiation oncologist and new treatment plans were generated on the weekly CT scans for all patients. For each DIR process, four deformation vector fields (DVFs) were generated to propagate contours and accumulate weekly dose by the following algorithms: (a) ANACONDA with simple presetting parameters, (b) ANACONDA with detailed presetting parameters, (c) MORFEUS with simple presetting parameters, and (d) MORFEUS with detailed presetting parameters. The geometric evaluation considered DICE coefficient and Hausdorff distance. The dosimetric evaluation included D95 , Dmax , Dmean , Dmin , and Homog...Continue Reading

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Citations

Nov 8, 2019·The British Journal of Radiology·Suliana TeohFrank Van den Heuvel
Sep 21, 2019·Journal of Applied Clinical Medical Physics·Makoto SasakiTakashi Mizowaki
Jan 21, 2021·International Journal of Radiation Oncology, Biology, Physics·Carri K Glide-HurstEvan Wuthrick
Mar 28, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Lena NenoffFrancesca Albertini
May 14, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Edoardo MastellaMario Ciocca

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Software Mentioned

MORFEUS
RayStation
ANACONDA
RayStation TPS
ART
RayStation ART

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