The Impact of Salts on the Ice Recrystallization Inhibition Activity of Antifreeze (Glyco)Proteins

Biomolecules
Romà Surís-Valls, Ilja K Voets

Abstract

Antifreeze (glyco)proteins (AF(G)Ps) have received increasing attention as potential cryopreservation agents since their discovery in the 1970s. While cryopreservation strategies for specific cells (such as red blood cells) are successful and widely implemented, preservation of other cell types, tissues and whole organs remains challenging. This is due to the multifactorial nature of the freeze-thaw damage, the complexity of preserving biological matter and the (country-to-country) variability of the employed procedures and regulations. AF(G)Ps are well-known for their ability to modulate ice crystal growth morphology and ice recrystallization inhibition (IRI), both of which are considered key contributors to freeze-thaw damage. To date, however, the impact of AF(G)Ps on cell survival remains at best partially understood as conflicting results on the benefits or disadvantages of including AF(G)P in cryopreservation strategies remain unelucidated. We hypothesize that variability in the additives in the cryopreservation media contributes to the observed discrepancies. To critically examine this idea, we monitored the inhibition of ice recrystallization by AF(G)P in the presence of various salts using a quantitative analysis of op...Continue Reading

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Citations

Oct 20, 2019·International Journal of Molecular Sciences·Romà Surís-Valls, Ilja K Voets
Apr 9, 2020·The Analyst·Alice FayterMatthew I Gibson
Oct 23, 2020·Extremophiles : Life Under Extreme Conditions·Elizabeth A DeleskyWil V Srubar
Mar 12, 2020·International Journal of Biological Macromolecules·Hong XiangYong Hu
Dec 1, 2021·Biomacromolecules·Huba L MartonMatthew I Gibson

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