Abstract
Although several previous studies have found a positive association between ambient ozone and mortality, the observed effect may be confounded by other secondary pollutants that are produced concurrently with ozone. We addressed the question of whether the ozone-mortality relationship is entirely a reflection of the adverse effect of ozone, or whether it is, at least in part, an effect of other secondary pollutants. Separate time-series models were fit to 3-6 years of data between 2000 and 2005 from 18 U.S. communities. The association between nonaccidental mortality was examined with ozone alone and with ozone after adjustment for fine particle mass, sulfate, organic carbon, or nitrate concentrations. The effect estimates from each of these models were pooled using a random-effects meta-analysis to obtain an across-community average. We found a 0.89% [95% confidence interval (CI), 0.45-1.33%] increase in nonaccidental mortality with a 10-ppb increase in same-day 24-hr summertime ozone across the 18 communities. After adjustment for PM(2.5) (particulate matter with aerodynamic diameter <or= 2.5 microm) mass or nitrate, this estimate decreased slightly; but when adjusted for particle sulfate, the estimate was substantially reduc...Continue Reading
References
Dec 5, 1998·Statistics in Medicine·C S BerkeyG A Colditz
Mar 22, 2000·Circulation·D R GoldR Verrier
May 16, 2000·Environmental Health Perspectives·S L ZegerA Cohen
Jun 16, 2000·Environmental Health Perspectives·J Schwartz
Jun 2, 2001·Environmental Research·M S GoldbergM F Valois
Sep 26, 2001·Journal of Exposure Analysis and Environmental Epidemiology·G D Thurston, K Ito
Oct 25, 2001·Environmental Health Perspectives·J A SarnatH H Suh
Sep 3, 2002·Environmental Health Perspectives·Alfésio L F BragaJoel Schwartz
May 24, 2003·Epidemiologic Reviews·Rupa Basu, Jonathan M Samet
Jul 30, 2004·American Journal of Respiratory and Critical Care Medicine·Alexandros GryparisZeynep Dörtbudak
Nov 18, 2004·JAMA : the Journal of the American Medical Association·Michelle L BellFrancesca Dominici
Dec 8, 2004·American Journal of Respiratory and Critical Care Medicine·Joel Schwartz
Apr 13, 2005·Epidemiology·Jeremy A SarnatPetros Koutrakis
Jun 2, 2005·Circulation·Marie S O'NeillJoel Schwartz
Jun 14, 2005·Epidemiology·Michelle L BellJonathan M Samet
Jun 14, 2005·Epidemiology·Kazuhiko ItoMorton Lippmann
Jun 14, 2005·Epidemiology·Jonathan I LevyJeremy A Sarnat
Jun 8, 2006·Occupational and Environmental Medicine·S E SarnatD R Gold
Aug 12, 2006·Journal of Occupational and Environmental Medicine·Heike Luttmann-GibsonDiane R Gold
Sep 29, 2006·Journal of Exposure Science & Environmental Epidemiology·Meredith FranklinJoel Schwartz
Dec 22, 2006·Occupational and Environmental Medicine·M S O'NeillJ Schwartz
Apr 28, 2007·American Journal of Respiratory and Critical Care Medicine·Kai-Jen ChuangChin-Sheng Tang
May 24, 2007·Environmental Health Perspectives·Dan MaynardJoel Schwartz
Jun 15, 2007·Journal of Occupational and Environmental Medicine·Kai-Jen ChuangChung-Te Lee
Jul 20, 2007·Environmental Health Perspectives·Michelle L BellJonathan M Samet
Aug 10, 2007·Inhalation Toxicology·Richard B Schlesinger
Nov 17, 2007·Environmental Health Perspectives·Michelle L BellFrancesca Dominici
Citations
Jun 3, 2008·Environmental Health : a Global Access Science Source·Antonella Zanobetti, Joel Schwartz
Dec 23, 2009·Environmental Health : a Global Access Science Source·Antonella ZanobettiJoel Schwartz
Jan 23, 2010·Environmental Health : a Global Access Science Source·Cizao RenJoel Schwartz
Feb 18, 2010·Epidemiology·Francesca DominiciMichelle L Bell
Oct 9, 2012·American Journal of Epidemiology·G Brooke AndersonMichelle L Bell
Jan 2, 2016·The Journal of Physical Chemistry Letters·Shinichi EnamiAgustín J Colussi
Jun 23, 2016·Journal of the Air & Waste Management Association·Qian DiJoel Schwartz
Dec 14, 2011·Environmental Health Perspectives·Yebin TaoTong Zhu
May 12, 2010·Circulation·Robert D BrookUNKNOWN American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Coun
Feb 11, 2018·Scientific Reports·Yaohua TianYonghua Hu
May 5, 2010·American Journal of Epidemiology·Kelly MooreIra Tager
Jul 10, 2014·Journal of Exposure Science & Environmental Epidemiology·Elena AustinPetros Koutrakis
Jun 26, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Matteo GoldoniAntonio Mutti
Mar 27, 2010·American Journal of Respiratory and Critical Care Medicine·Massimo StafoggiaUNKNOWN EpiAir Group
May 25, 2011·Inhalation Toxicology·Joe L MauderlySteven K Seilkop
May 23, 2013·American Journal of Epidemiology·Sonja Sax, Julie E Goodman
Jul 22, 2018·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Jun KuraiMasanari Watanabe
Oct 5, 2013·Critical Reviews in Toxicology·Julie E GoodmanLorenz R Rhomberg
Sep 27, 2014·Critical Reviews in Toxicology·Robyn L PrueittJulie E Goodman
Sep 27, 2014·Critical Reviews in Toxicology·Julie E GoodmanFerdinand J Venditti
Feb 3, 2015·Epidemiology·Jonathan M SnowdenIra B Tager
May 12, 2015·Critical Reviews in Toxicology·Julie E GoodmanFerdinand J Venditti
Sep 8, 2009·Inhalation Toxicology·Richard L SmithPaul Switzer
Mar 18, 2015·American Journal of Epidemiology·Katherine GassMatthew J Strickland
Jul 31, 2013·American Journal of Epidemiology·G Brooke AndersonMichelle L Bell
Jul 28, 2012·Environmental Science & Technology·Kim M LichtveldHarvey E Jeffries
Mar 22, 2016·Environmental Science & Technology·Yadong XuWilliam Vizuete