The impact of severe hypoglycemia on renal impairment in type 2 diabetes

Diabetes Research and Clinical Practice
Yu-Li LeeShyi-Jang Shin

Abstract

Hypoglycemia has been reported to be associated with the development of microvascular events. Therefore, it is important to assess the impact of severe hypoglycemia on renal dysfunction in type 2 diabetes. We conducted a retrospective cohort study in a large tertiary care hospital from 2004 to 2013. A total of 101 patients with type 2 diabetes from the outpatient department with a history of severe hypoglycemia were studied. A random sample of 101 patients with type 2 diabetes without any hypoglycemia was selected by matching values of baseline blood creatinine, age, sex and diabetic duration. Baseline blood creatinine (1.42 ± 0.75 mg/dL) significantly increased to 1.77 ± 1.26 and 1.93 ± 1.54 mg/dL, and baseline eGFR (44.37 ± 26.13 ml/min/1.73 m(2)) decreased to 41.28 ± 27.70 and 37.64 ± 24.54 ml/min/1.73 m(2) at the onset of hypoglycemia and the follow-up visit in severe hypoglycemia group; while no significant changes were observed in the group without any hypoglycemia. Multiple linear regression analysis showed that severe hypoglycemia is an independent risk factor for increase in blood creatinine and decrease in eGFR in all patients with type 2 diabetes, and that baseline creatinine, longer diabetic duration and lower HbA1c...Continue Reading

References

Feb 8, 2008·The New England Journal of Medicine·Peter GaedeOluf Pedersen
May 8, 2008·Diabetes/metabolism Research and Reviews·Rohana J Wright, Brian M Frier
Jun 10, 2008·The New England Journal of Medicine·Anushka PatelFlorence Travert
Jun 10, 2008·The New England Journal of Medicine·Robert G Dluhy, Graham T McMahon
Sep 12, 2008·The New England Journal of Medicine·Rury R HolmanH Andrew W Neil
May 9, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Maureen F MoenJeffrey C Fink
Jul 22, 2009·Annals of Internal Medicine·Tanika N KellyJiang He
May 29, 2010·Diabetes Care·Cyrus V DesouzaVivian Fonseca
Oct 12, 2010·The New England Journal of Medicine·Sophia ZoungasUNKNOWN ADVANCE Collaborative Group
Aug 28, 2012·Diabetes Care·Philip E Cryer
Oct 17, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN National Kidney Foundation
Apr 17, 2013·The Journal of Clinical Endocrinology and Metabolism·Elizabeth R SeaquistUNKNOWN Endocrine Society
Mar 19, 2014·Diabetes Research and Clinical Practice·L GuariguataJ E Shaw
Aug 2, 2014·Clinical Interventions in Aging·Richard E Pratley
Sep 27, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Katherine R TuttleMark E Molitch

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Citations

Mar 1, 2019·International Journal of Environmental Research and Public Health·Yu-Li LeeKun-Der Lin
Feb 24, 2021·Scientific Reports·Jae-Seung YunSeung-Hyun Ko
Sep 17, 2021·Journal of Diabetes Investigation·Jun-Sing WangUNKNOWN Diabetes Kidney Disease Research Committee of the Diabetes Association of the Republic of China (Taiwan)

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