The impact of sex in primary glomerulonephritis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Daniel C CattranGenes, Gender and Glomerulonephritis Group

Abstract

Studies comparing the impact of sex in primary glomerular disease have reported conflicting results. We analysed 395 membranous (MGN), 370 focal and segmental glomerulosclerosis (FSGS) and 542 IgA nephropathy patients to determine the impact of the patients' sex on outcome. We assessed initial and follow-up blood pressure, proteinuria, anti-hypertensive and immunosuppressive therapy, rate of renal function decline and survival from renal failure or a 50% decrease in creatinine clearance (combined event). Women accounted for one-third of the cohort. At presentation they were on average 2 years younger than men, and over follow-up received no more immunosuppression or anti-hypertensive agents than their male counterpart. Their mean arterial pressure (MAP) overall was 2 mmHg lower. Proteinuria at presentation and during follow-up in women compared to men was 50% and 30% lower in MGN and FSGS, while no differences were seen in IgA nephropathy. The rate of renal function decline and outcome favoured women over men in MGN (hazard ratios of a combined event of 0.63, 95% CI 0.40-1.00, P = 0.05) and in FSGS (HR 0.67, 95% CI 0.48-0.95, P = 0.02) but not in IgA nephropathy. These differences were not independent of blood pressure and prot...Continue Reading

References

Dec 13, 1979·The New England Journal of Medicine·UNKNOWN Collaborative Study of the Adult Idiopathic Nephrotic Syndrome
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Dec 1, 1991·Kidney International·S RekolaH Bucht
Jul 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E AlamartineF Berthoux
Apr 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J S Cameron
Mar 1, 1988·Kidney International·J V DonadioC P Chu
Jan 1, 1984·Contributions to Nephrology·D DrozL H Noël
Jan 1, 1981·Nephron·J HopperC G Biava
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J SchaefferK M Koch
Apr 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S R Silbiger, J Neugarten
Apr 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J J RydelM M Schwartz
Jan 1, 1994·International Urology and Nephrology·T Tóth, S Takebayashi
Jul 8, 1993·The New England Journal of Medicine·A SchieppatiG Remuzzi
Feb 1, 1997·Journal of the American Society of Nephrology : JASN·M G RadfordJ P Grande
Apr 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A KoyamaM Kobayashi
Jun 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M Haas
Feb 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L FrimatM Kessler
Jun 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C H CogginsS R Wang
Jan 20, 1999·Kidney International·J A MillerD C Cattran
Sep 7, 1999·Journal of the American Society of Nephrology : JASN·M M SchwartzS M Korbet
Feb 9, 2000·Journal of the American Society of Nephrology : JASN·Joel NeugartenSharon R Silbiger
May 23, 2001·Hypertension·J F Reckelhoff
May 1, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hendrik BosGerjan Navis
May 31, 2002·QJM : Monthly Journal of the Association of Physicians·E B JudeA J M Boulton
Jan 28, 2003·Archives of Internal Medicine·Ashish Atreja, Neil Mehta
Sep 19, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tazeen H JafarAndrew S Levey
Aug 26, 2004·Kidney International·Stéphan TroyanovUNKNOWN Toronto Glomerulonephritis Registry Group
Feb 18, 2005·Journal of the American Society of Nephrology : JASN·Stéphan TroyanovUNKNOWN Toronto Glomerulonephritis Registry Group
Mar 21, 2006·Metabolism: Clinical and Experimental·Johan VerbraeckenLuc Van Gaal
Apr 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Philip Kam-Tao LiUNKNOWN HKVIN Study Group

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Citations

May 20, 2011·World Journal of Urology·Peir-Haur HungKuan-Yu Hung
Jun 21, 2013·The New England Journal of Medicine·Robert J Wyatt, Bruce A Julian
Jul 2, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Markus P SchneiderRoland E Schmieder
Apr 29, 2011·Transplantation·Manuel AriasManuel Praga
Oct 27, 2010·PloS One·Heather N ReichMatthias Kretzler
Aug 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Michelle A HladunewichUNKNOWN Metropolitan Toronto Glomerulonephritis Registry
Jul 17, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Yu-Hsiang ChouYung-Ming Chen
Oct 28, 2011·Clinical Medicine & Research·Manouchehr NakhjavaniAlireza Farokhian
Nov 13, 2008·Clinical Nephrology·S PrakashD C Cattran
Mar 25, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard J Glassock
Jul 5, 2013·Avicenna Journal of Medicine·Ziad Arabi
Jun 4, 2014·The Journal of Clinical Investigation·Krzysztof Kiryluk, Jan Novak
Jul 19, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sebastian KummerJun Oh
Aug 5, 2015·Journal of Clinical Medicine·Christos ArgyropoulosJohn P Johnson
May 18, 2016·Nature Reviews. Disease Primers·Kar Neng LaiRichard J Glassock
Aug 28, 2013·Advances in Chronic Kidney Disease·Joel Neugarten, Ladan Golestaneh
Jun 1, 2012·Kidney International Supplements
Feb 1, 2011·Kidney International·Sharon R Silbiger
Apr 14, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sean J Barbour, Heather N Reich
Mar 28, 2012·Advances in Chronic Kidney Disease·Mark Haas, Heather N Reich
Jul 21, 2009·Biochemical and Biophysical Research Communications·Daniela VerzolaGiacomo Garibotto
Apr 23, 2014·European Journal of Clinical Investigation·Dominik G HaiderAfschin Soleiman
Feb 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Richard J Glassock
Dec 20, 2008·American Journal of Hypertension·Maciej TomaszewskiEwa Zukowska-Szczechowska
Aug 17, 2010·Expert Opinion on Pharmacotherapy·Claudio Ponticelli, Patrizia Passerini
Jun 17, 2015·Journal of the American Society of Nephrology : JASN·Aliza ThompsonPatrick H Nachman
Apr 14, 2019·JAMA Internal Medicine·Sean J BarbourUNKNOWN International IgA Nephropathy Network
Jan 13, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Aliza ThompsonPatrick H Nachman
Nov 23, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Gemma BullichElisabet Ars
Oct 1, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Elion HoxhaRolf A K Stahl
Oct 5, 2019·Journal of Clinical Medicine·Bogdan ObrișcăGabriel Mircescu
Feb 16, 2019·Nature Reviews. Nephrology·Richard J Glassock
Mar 16, 2017·International Journal of Endocrinology·Jimena SouteloOsvaldo Juan Ponzo
May 27, 2011·American Journal of Physiology. Renal Physiology·Virginia ReverteF Javier Salazar
Apr 27, 2017·American Journal of Nephrology·Michelle M O'ShaughnessyWilliam F Pendergraft
Nov 7, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michelle M O'ShaughnessyJ Charles Jennette
Jun 4, 2020·Biology of Sex Differences·Andrea Rodrigues Sabbatini, Georgios Kararigas
Sep 28, 2017·Scientific Reports·Ixchel Lima-PosadaNorma A Bobadilla
Sep 15, 2017·BioMed Research International·Andreas KronbichlerJae Il Shin
Sep 19, 2020·International Urology and Nephrology·Dongmei WenWei Qin

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