The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity.

Cellular Signalling
Robbert HavekesTed Abel

Abstract

Sleep deprivation is a common feature in modern society, and one of the consequences of sleep loss is the impairment of cognitive function. Although it has been widely accepted that sleep deprivation affects learning and memory, only recently has research begun to address which molecular signaling pathways are altered by sleep loss and, more importantly, which pathways can be targeted to reverse the memory impairments resulting from sleep deprivation. In this review, we discuss the different methods used to sleep deprive animals and the effects of different durations of sleep deprivation on learning and memory with an emphasis on hippocampus-dependent memory. We then review the molecular signaling pathways that are sensitive to sleep loss, with a focus on those thought to play a critical role in the memory and synaptic plasticity deficits observed after sleep deprivation. Finally, we highlight several recent attempts to reverse the effects of sleep deprivation on memory and synaptic plasticity. Future research building on these studies promises to contribute to the development of novel strategies to ameliorate the effects of sleep loss on cognition.

References

Apr 1, 1977·Behavioral Biology·W Fishbein, B M Gutwein
Sep 16, 1992·Biochemical and Biophysical Research Communications·F LibertK D Mendla
Nov 1, 1990·Physiology & Behavior·P Ramm, C T Smith
Feb 1, 1989·Physiology & Behavior·M Lancel, G A Kerkhof
Aug 1, 1973·Physiology & Behavior·C Pearlman
May 1, 1983·Physiology & Behavior·M Isokawa, M Shimokochi
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Mar 1, 1995·Progress in Neurobiology·J H Benington, H C Heller
Feb 1, 1997·Physiology & Behavior·B D YoungbloodR B Harris
Feb 1, 1997·The European Journal of Neuroscience·H NakanishiL Sokoloff
May 23, 1997·Science·T Porkka-HeiskanenR W McCarley
Jul 4, 1998·Brain Research. Brain Research Reviews·T Abel, E Kandel
Jan 19, 2000·Progress in Neurobiology·M R Bennett
Apr 20, 2000·European Journal of Pharmacology·M AlkondonE X Albuquerque
Jun 6, 2000·Neuron·S J ScalesR H Scheller
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Dec 29, 2000·Cellular and Molecular Life Sciences : CMLS·C Mazzucchelli, R Brambilla
Mar 16, 2001·Trends in Neurosciences·L GravesT Abel
Jul 5, 2001·Physiology & Behavior·P MeerloS Daan
Aug 25, 2001·Annual Review of Neuroscience·S Maren
Oct 5, 2001·Lancet·S M Rajaratnam, J Arendt
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G Tononi, C Cirelli
Jun 18, 2003·The Journal of Biological Chemistry·Graeme B BolgerMiles D Houslay
Dec 9, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Benno Roozendaal
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anne Kemp, Denise Manahan-Vaughan
Jun 9, 2004·The European Journal of Neuroscience·David N RuskinGerald J LaHoste
Jun 15, 2004·Current Opinion in Neurobiology·J David Sweatt
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Boyer D WintersTimothy J Bussey
Dec 16, 2004·Journal of Neural Transmission·Q Zhang, P G Haydon
Dec 22, 2004·The European Journal of Neuroscience·Rodrigo Romcy-Pereira, Constantine Pavlides
Feb 18, 2005·Journal of Neurochemistry·Nirinjini NaidooAllan I Pack
May 18, 2005·Learning & Memory·Theresa E BjornessGina R Poe

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Citations

Aug 30, 2012·Physiological Genomics·Christopher G VecseyTed Abel
Jun 12, 2013·Respiratory Physiology & Neurobiology·Silvia PagliardiniClayton T Dickson
Jul 22, 2014·Neurobiology of Learning and Memory·Andrew W VargaEric Klann
Dec 3, 2014·The Psychiatric Clinics of North America·Michel A Woodbury-Fariña
Jan 29, 2013·Sleep Medicine·Jose-Alberto PalmaJorge Iriarte
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kristine YaffeKarl E Friedl
Sep 13, 2015·Neurochemistry International·Renu WadhwaSunil C Kaul
Mar 22, 2015·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Kristine YaffeAmy Byers
Jan 9, 2014·Medical Hypotheses·Mauro ZappaterraSanjog Pangarkar
Sep 14, 2013·Current Biology : CB·Ted AbelMatthew P Walker
Aug 3, 2013·Behavioural Brain Research·Vanessa Athaíde GarciaMonica Levy Andersen
Apr 28, 2016·Science Signaling·Jennifer C TudorTed Abel
Jul 10, 2013·Neurobiology of Learning and Memory·Morgan S Bridi, Ted Abel
Sep 19, 2014·Lancet Neurology·Kristine YaffeTina Hoang
Jan 24, 2015·American Journal of Alzheimer's Disease and Other Dementias·Jing XuGang Wang
Nov 18, 2017·International Journal of Molecular Sciences·Mounir ChennaouiDanielle Gomez-Merino
Dec 13, 2017·Child: Care, Health and Development·S Hanafin
Apr 17, 2013·Physiological Reviews·Björn Rasch, Jan Born
Sep 14, 2019·Journal of Sleep Research·Sahar El AidyRobbert Havekes
Jan 20, 2017·Molecular Neurobiology·Karem H AlzoubiFeras Q Alali
Oct 28, 2018·Scientific Reports·Sibah HasanStuart N Peirson
Jun 26, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Maede RezaieMohammad Ali Nasiri Khalili
Nov 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Karim Fifel
Sep 7, 2018·Neural Plasticity·Monica ChristovaEugen Gallasch
Jan 31, 2020·Journal of Applied Physiology·Matthew D ReganC Loren Buck
Jan 1, 2016·AIMS Neuroscience·Mark R ZielinskiRobert W McCarley
Jul 30, 2019·JNCI Cancer Spectrum·Kevin T LiouJun J Mao
Aug 11, 2020·Frontiers in Molecular Neuroscience·Andrew J Kesner, David M Lovinger
Mar 15, 2018·Frontiers in Neural Circuits·Marie E GaineTed Abel
Mar 19, 2019·Current Psychiatry Reports·Jennifer R Goldschmied, Philip Gehrman
Jan 10, 2019·Neuroscience and Biobehavioral Reviews·Jennaya ChristensenRichelle Mychasiuk

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