The impact of smoking and smoking cessation on disease outcomes in ulcerative colitis: a nationwide population-based study

Alimentary Pharmacology & Therapeutics
Jonathan BlackwellRichard C Pollok

Abstract

Smokers are less likely to develop ulcerative colitis (UC) but the impact of smoking and subsequent cessation on clinical outcomes in UC is unclear. To evaluate the effect of smoking status and smoking cessation on disease outcomes. Using a nationally representative clinical research database, we identified incident cases of UC during 2005-2016. Patients were grouped as never-smokers, ex-smokers and smokers based on smoking status recorded in the 2 years preceding UC diagnosis. We defined subgroups of persistent smokers and smokers who quit within 2 years after diagnosis. We compared the rates of overall corticosteroid use, corticosteroid-requiring flares, corticosteroid dependency, thiopurine use, hospitalisation and colectomy between these groups. We identified 6754 patients with a new diagnosis of UC over the study period with data on smoking status, of whom 878 were smokers at diagnosis. Smokers had a similar risk of corticosteroid-requiring flares (OR 1.16, 95% CI 0.92-1.25), thiopurine use (HR 0.84, 95% CI 0.62-1.14), corticosteroid dependency (HR 0.85, 95% CI 0.60-1.11), hospitalisation (HR 0.92, 95% CI 0.72-1.18) and colectomy (HR 0.78, 95% CI 0.50-1.21) in comparison with never-smokers. Rates of flares, thiopurine use,...Continue Reading

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Citations

May 7, 2020·Alimentary Pharmacology & Therapeutics·Stamatia PapoutsopoulouChris S Probert
Apr 1, 2020·The American Journal of Gastroenterology·Jacob J RozichSiddharth Singh
Oct 23, 2020·World Journal of Gastroenterology : WJG·Eun Ae KangJoo Sung Kim
Jul 20, 2021·Inflammatory Bowel Diseases·Gaurav SyalAlan C Moss
Aug 14, 2021·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Rintaro MoroiAtsushi Masamune
Mar 19, 2021·Journal of Crohn's & Colitis·Claudio FiocchiUNKNOWN Scientific Workshop Steering Committee

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