The impact of smoking on long-term outcome of patients with premature (≤35years) ST-segment elevation acute myocardial infarction

American Heart Journal
Loukianos S RallidisJonh Lekakis

Abstract

There are few data regarding the long-term prognosis of young survivors of acute myocardial infarction (AMI). We explored the long-term outcome in individuals who had sustained a premature ST-segment elevation AMI. We recruited 257 consecutive patients who had survived their first AMI ≤35years of age. Patients were followed up for up to 18years. Clinical end points included all major adverse coronary events (MACE): cardiac death, readmission for acute coronary syndrome, arrhythmias, or coronary revascularization due to clinical deterioration. The most prevalent risk factor at presentation was smoking (93.7%). Follow-up data were obtained from 237 patients (32.2±3.7years old). The median follow-up period was 9.1years. During follow-up, 139 (58.6%) patients reported continuation of smoking. Ninety-one (38.4%) patients had recurrent MACE (13 deaths, 59 acute coronary syndromes, 2 arrhythmias, and 17 revascularizations). Multivariable Cox regression analysis showed that persistence of smoking, left ventricular ejection fraction (LVEF), and reperfusion therapy (fibrinolysis or primary coronary angioplasty) were independent predictors of MACE after adjustment for conventional risk factors. Continuation of smoking remained an independ...Continue Reading

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Citations

Aug 25, 2015·European Journal of Internal Medicine·Stephane Fournier, Olivier Muller
Feb 18, 2016·European Journal of Clinical Investigation·Max-Paul WinterGeorg Goliasch
Jul 19, 2016·Current Opinion in Cardiology·Loukianos S Rallidis, George Pavlakis
Sep 8, 2017·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jing SunYu-Ming Li
Sep 10, 2017·Neurology·Katherine A EpsteinUNKNOWN IRIS Trial Investigators
Nov 18, 2017·Medwave·Alvaro Gudiño GomezjuradoGustavo Aguiar Sousa
Sep 1, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Amanda EkMats Börjesson
Jan 30, 2021·British Journal of Hospital Medicine·David Maud, Muhammad A Sajjad

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