The impact of social stress during adolescence or adulthood and coping strategy on cognitive function of female rats

Behavioural Brain Research
Kevin SnyderRita J Valentino

Abstract

The age of stressor exposure can determine its neurobehavioral impact. For example, exposure of adolescent male rats to resident-intruder stress impairs cognitive flexibility in adulthood. The current study examined the impact of this stressor in female rats. Rats were exposed to resident-intruder stress during early adolescence (EA), mid-adolescence (MA) or adulthood (Adult). They were tested in an operant strategy-shifting task for side discrimination (SD), reversal learning (REV) and strategy set-shifting (SHIFT) the following week. Performance varied with age, stress and coping style. MA and EA rats performed SD and SHIFT better than other ages, respectively. Social stress impaired performance in rats depending on their coping strategy as determined by a short (SL) or long (LL) latency to become subordinate. SL rats were impaired in SD and REV, whereas EA-LL rats were impaired in SHIFT. These impairing effects of female adolescent stress did not endure into adulthood. Strategy set-shifting performance for female adolescents was positively correlated with medial prefrontal cortex (mPFC) activation as indicated by c-fos expression suggesting that this region is engaged during task performance. This contrasts with the inverse ...Continue Reading

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Citations

Sep 12, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gerard A ZitnikRita J Valentino
Apr 14, 2016·Neuroscience·Jessica L Hurtubise, John G Howland
Dec 15, 2016·Frontiers in Behavioral Neuroscience·Ellen KanitzBirger Puppe
Apr 8, 2017·Frontiers in Behavioral Neuroscience·Tatiana A ShnitkoKathleen A Grant
Feb 2, 2021·Neurobiology of Stress·Mona FariborziGyorgy Lur

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