The impact of statin use on atrial fibrillation

QJM : Monthly Journal of the Association of Physicians
J Sánchez-QuiñonesGregory Y H Lip

Abstract

The aim of the present systematic review is to present an overview of the evidence linking atrial fibrillation (AF), inflammation and oxidative stress, with emphasis on the potential of statins to decrease the incidence of different types of AF, including new-onset AF, after electrical cardioversion (EC) and after cardiac surgery. Observational and clinical trials have studied the impact of statin therapy on new-onset, post-EC or postoperative AF. Data from different observational trials have shown that treatment with statins significantly reduces the incidence of new-onset AF in the primary and secondary prevention. The data are insufficient to recommend the use of statins before EC. Finally, perioperative statin therapy may represent an important non-antiarrhythmic adjunctive therapeutic strategy for the prevention of postoperative AF.

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Citations

Oct 29, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Diana Hernández-RomeroFrancisco Marín
Jan 20, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Anthony S Wierzbicki, Adie Viljoen
Aug 2, 2011·Thrombosis Research·Silvia Montoro-GarcíaGregory Y H Lip
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Aug 22, 2009·Journal of the American College of Cardiology·David J Wilber
Oct 16, 2012·International Journal of Cardiology·Esteban Orenes-PiñeroGregory Y H Lip
Mar 1, 2018·Immunopharmacology and Immunotoxicology·Mahya NajjariVahid Nikoui
Jul 20, 2017·Current Medicinal Chemistry·Alexios S AntonopoulosDimitris Tousoulis
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