The impact of stress on the prevalence of prednisolone in bovine urine: A metabolic fingerprinting approach

The Journal of Steroid Biochemistry and Molecular Biology
Nathalie De ClercqLynn Vanhaecke

Abstract

Recent studies support the hypothesis that the glucocorticoid prednisolone can be formed from cortisol under influence of stress. To evaluate this hypothesis, urine samples of supposedly non-stressed bovines (at the farm) and bovines subjected to two different forms of stress, i.e. upon slaughter (natural stress) or following administration of a synthetic analog of the adrenocorticotropic hormone (pharmacologically-induced stress) were analysed, and their urinary cortisol and prednisolone levels evaluated. At the farm, none of the examined samples exhibited urinary prednisolone levels higher than the CCα (0.09 μg L(-1)). Upon slaughter or following synthetically induced stress, significantly positive correlations between cortisol and prednisolone could be demonstrated, 0.52 and 0.69, respectively. Of all prednisolone-positive urine samples (n=84), only one showed a prednisolone levels (i.e. 6.45 μg L(-1)) above the threshold level of 5 μg L(-1) suggested by the European Reference Laboratories. Subsequently, an untargeted analysis was performed (metabolic fingerprinting) to characterize the urinary metabolite patterns related to the three different cattle groups. In this context, multivariate statistics assigned a total of 169 d...Continue Reading

References

Jan 1, 1992·Neuroscience and Biobehavioral Reviews·E O JohnsonP W Gold
Aug 20, 1988·The Veterinary Record·G MitchellM Ganhao
May 18, 1995·The New England Journal of Medicine·G P Chrousos
Oct 16, 2002·Journal of Psychosomatic Research·Constantine Tsigos, George P Chrousos
Mar 26, 2003·Journal of Chemical Information and Computer Sciences·Douglas M HawkinsDenise Mills
Mar 28, 2007·Analytica Chimica Acta·M H BloklandR W Stephany
Jan 24, 2009·Journal of Analytical Toxicology·Edward J ConeDavid L Black
Jul 22, 2009·Analytical Chemistry·Jeroen C W RijkMichel W F Nielen
May 4, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Michael BredehöftWilhelm Schänzer
Apr 9, 2011·Stroke; a Journal of Cerebral Circulation·Jee Youn JungGeum-Sook Hwang
Aug 8, 2012·Swiss Medical Weekly·Rowan S HardyMark S Cooper
Sep 12, 2012·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M VincentiC Nebbia
Apr 10, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Luigi BertocchiFrancesco Arioli
Jan 8, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Eva de RijkeLeendert A van Ginkel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
M VincentiC Nebbia
Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Francesco ArioliL Chiesa
© 2021 Meta ULC. All rights reserved